Liu YS, Li HS, Qi DF, Zhang J, Jiang XC, Shi K, Zhang XJ, Zhang XH. Zinc protoporphyrin IX enhances chemotherapeutic response of hepatoma cells to cisplatin. World J Gastroenterol 2014; 20(26): 8572-8582 [PMID: 25024611 DOI: 10.3748/wjg.v20.i26.8572]
Corresponding Author of This Article
Xin-Hui Zhang, MD, The Central Hospital of Xuzhou City, Xuzhou Hospital Affiliated to Medical College of Southeast University, Jiefang Rd, Xuzhou 221009, Jiangsu Province, China. 88liuyin888@163.com
Research Domain of This Article
Hematology
Article-Type of This Article
Original Article
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Jul 14, 2014; 20(26): 8572-8582 Published online Jul 14, 2014. doi: 10.3748/wjg.v20.i26.8572
Zinc protoporphyrin IX enhances chemotherapeutic response of hepatoma cells to cisplatin
Yang-Sui Liu, Huan-Song Li, Dun-Feng Qi, Jun Zhang, Xin-Chun Jiang, Kui Shi, Xiao-Jun Zhang, Xin-Hui Zhang
Yang-Sui Liu, Huan-Song Li, Dun-Feng Qi, Jun Zhang, Xin-Chun Jiang, Kui Shi, Xiao-Jun Zhang, Xin-Hui Zhang, The Central Hospital of Xuzhou City, Xuzhou Hospital Affiliated to Medical College of Southeast University, Xuzhou 221009, Jiangsu Province, China
Author contributions: Liu YS and Zhang XH performed the majority of experiments; Li HS, Zhang J and Zhang XJ provided vital reagents and analytical tools and were also involved in revising the manuscript; Qi DF, Jiang XC and Shi K analyzed the data; Liu YS, Zhang XJ and Zhang XH designed the study and wrote the manuscript.
Supported by Xuzhou City Health Bureau Project, China, No. XZZD1128; and Xuzhou City Municipal Science and Technology Bureau Project, China, No. XWJ2011040
Correspondence to: Xin-Hui Zhang, MD, The Central Hospital of Xuzhou City, Xuzhou Hospital Affiliated to Medical College of Southeast University, Jiefang Rd, Xuzhou 221009, Jiangsu Province, China. 88liuyin888@163.com
Telephone: +86-516-83956131 Fax: +86-516-83956131
Received: November 13, 2013 Revised: January 14, 2014 Accepted: April 2, 2014 Published online: July 14, 2014
Core Tip
Core tip: Overexpression of heme oxygenase (HO)-1 in HepG2 cell line was associated with increased chemoresistance to cis-diaminedichloroplatinum (cisplatin; CDDP) compared to other cell lines. Inhibition of HO-1 expression by zinc protoporphyrin IX (ZnPP IX) markedly augmented CDDP-mediated cytotoxicity towards other hepatoma cells. Induction of HO-1 with hemin increased resistance of tumor cells to CDDP-mediated cytotoxicity. Furthermore, cells treated with ZnPP IX plus CDDP exhibited marked production of intracellular reactive oxygen species (ROS) and caspase-3 activity, whereas hemin decreased cellular ROS and caspase-3 activity induced by CDDP. Therefore, administration of HO-1 inhibitors may evolve into a new liver cancer treatment strategy.
