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World J Gastroenterol. Jul 14, 2014; 20(26): 8525-8534
Published online Jul 14, 2014. doi: 10.3748/wjg.v20.i26.8525
Published online Jul 14, 2014. doi: 10.3748/wjg.v20.i26.8525
High fat diet feeding results in gender specific steatohepatitis and inflammasome activation
Michal Ganz, Timea Csak, Gyongyi Szabo, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, United States
Author contributions: All the authors contributed to studying concept and design, acquisition, analysis and interpretation of data; Ganz M and Szabo G contributed to drafting of the manuscript; Csak T and Szabo G contributed to critical revision of the manuscript for important intellectual content; Szabo G contributed to obtained funding, study supervision.
Supported by National Institutes of Health Grant, No. DK075635
Correspondence to: Gyongyi Szabo, MD, PhD, Department of Medicine, University of Massachusetts Medical School, 364 Plantation St, LRB-208, Worcester, MA 01605, United States. gyongyi.szabo@umassmed.edu
Telephone: +1-508-8566113 Fax: +1-508-8564770
Received: December 18, 2012
Revised: April 11, 2013
Accepted: June 1, 2013
Published online: July 14, 2014
Revised: April 11, 2013
Accepted: June 1, 2013
Published online: July 14, 2014
Core Tip
Core tip: Our work shows that there are gender differences in the development of non-alcoholic steatohepatitis. We used a high fat diet feeding supplemented with fructose and sucrose in mice, to mimic the high-fructose corn syrup that is abundant in the western diet. There is preferential steatohepatitis and inflammasome activation in male mice, whereas female mice display steatosis without inflammation.