Published online Jul 14, 2014. doi: 10.3748/wjg.v20.i26.8525
Revised: April 11, 2013
Accepted: June 1, 2013
Published online: July 14, 2014
Core tip: Our work shows that there are gender differences in the development of non-alcoholic steatohepatitis. We used a high fat diet feeding supplemented with fructose and sucrose in mice, to mimic the high-fructose corn syrup that is abundant in the western diet. There is preferential steatohepatitis and inflammasome activation in male mice, whereas female mice display steatosis without inflammation.