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World J Gastroenterol. Jul 14, 2014; 20(26): 8325-8340
Published online Jul 14, 2014. doi: 10.3748/wjg.v20.i26.8325
Published online Jul 14, 2014. doi: 10.3748/wjg.v20.i26.8325
Proteomic and genomic studies of non-alcoholic fatty liver disease - clues in the pathogenesis
Jun Wei Lim, John Dillon, Michael Miller, Department of Gastroenterology, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom
Author contributions: Lim JW, Dillon J and Miller M contributed equally to this paper.
Correspondence to: Michael Miller, MBChB, MRCP, PhD, Specialist Registrar, Department of Gastroenterology, University of Dundee, Ninewells Hospital and Medical School, Dundee DD1 9SY, United Kingdom. m.miller@dundee.ac.uk
Telephone: +44-1382-632307 Fax: +44-1382-425504
Received: October 24, 2013
Revised: January 14, 2014
Accepted: April 1, 2014
Published online: July 14, 2014
Revised: January 14, 2014
Accepted: April 1, 2014
Published online: July 14, 2014
Core Tip
Core tip: Non-alcoholic fatty liver disease (NAFLD) is a widely prevalent hepatic disorder in Western populations. NAFLD can occur as a spectrum diseases, from simple steatosis, to non-alcoholic steatohepatitis characterised by hepatocellular injury and inflammation, to cirrhosis and hepatocellular carcinoma. This paper reviewed the current status of proteomic and genomic studies that have contributed to the understanding of NAFLD pathogenesis. This review highlighted several functional proteins and genetic polymoprhisms; particular those involved in insulin resistance, triglycerides metabolism and hepatic inflammation. It is hoped that this review will offer further insights into the pathophysiology of NAFLD.