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World J Gastroenterol. Jun 7, 2014; 20(21): 6671-6674
Published online Jun 7, 2014. doi: 10.3748/wjg.v20.i21.6671
Published online Jun 7, 2014. doi: 10.3748/wjg.v20.i21.6671
Rapid improvement in post-infectious gastroparesis symptoms with mirtazapine
Shinjini Kundu, Medical Scientist Training Program, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, United States
Shari Rogal, David J Levinthal, Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, United States
Abdulkader Alam, Department of Psychiatry, Stony Brook University Hospital, Stony Brook, NY 11794, United States
Author contributions: Kundu S, Rogal S, Alam A and Levinthal DJ designed the report and collected the patient’s clinical data; Kundu S, Rogal S and Levinthal DJ analyzed the data and wrote the paper.
Supported by University of Pittsburgh Medical Center, Pittsburgh PA, United States
Correspondence to: David J Levinthal, MD, PhD, Assistant Professor of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh Medical Center, M2 C-Wing PUH, 200 Lothrop Street, Pittsburgh, PA 15213, United States. levinthald@upmc.edu
Telephone: +1-412-3030525 Fax: +1-412-648-9378
Received: October 22, 2013
Revised: January 10, 2014
Accepted: March 5, 2014
Published online: June 7, 2014
Revised: January 10, 2014
Accepted: March 5, 2014
Published online: June 7, 2014
Core Tip
Core tip: The management of symptoms associated with severe gastroparesis remains challenging because current therapeutic options are fairly limited. This case report documents the rapid improvement of nausea and vomiting in a patient with severe post-infectious gastroparesis with mirtazapine. Because mirtazapine acts primarily as a serotonin 1a receptor agonist, this receptor system may be an important adjunctive target for nausea and vomiting refractory to standard therapies. Thus, mirtazapine should be considered as a treatment option for gastroparesis.