Observational Study
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World J Gastroenterol. Jun 7, 2014; 20(21): 6632-6637
Published online Jun 7, 2014. doi: 10.3748/wjg.v20.i21.6632
Potential role of human papilloma virus in the pathogenesis of gastric cancer
Miroslaw Snietura, Dariusz Waniczek, Wojciech Piglowski, Agnieszka Kopec, Ewa Nowakowska-Zajdel, Zbigniew Lorenc, Malgorzata Muc-Wierzgon
Miroslaw Snietura, Wojciech Piglowski, Agnieszka Kopec, Tumor Pathology Department, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, 44-101 Gliwice, Poland
Dariusz Waniczek, Zbigniew Lorenc, Clinical Department of General, Colorectal and Trauma Surgery, Silesian Medical University, 41-200 Sosnowiec, Poland
Ewa Nowakowska-Zajdel, Malgorzata Muc-Wierzgon, Department of Internal Diseases, Silesian Medical University, 41-902 Bytom, Poland
Author contributions: Snietura M and Waniczek D designed the study, directed its implementation and contributed to the analysis and interpretation of the data as well as to the redaction of the manuscript; Piglowski W and Kopec A performed the experiments and contributed to the collection of the materials and patient data; Nowakowska-Zajdel E, Lorenc Z and Muc-Wierzgon M contributed to the analysis and interpretation of the data.
Supported by Internal Research Grant of Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch
Correspondence to: Miroslaw Snietura, MD, PhD, Tumor Pathology Department, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, ul. Wybrzeze Armii Krajowej 15, 44-101 Gliwice, Poland. mirek@snietura.net
Telephone: +48-32-2789408 Fax: +48-32-2789415
Received: October 15, 2013
Revised: February 11, 2014
Accepted: March 8, 2014
Published online: June 7, 2014
Core Tip

Core tip: The study aimed to demonstrate the presence and biological activity of human papilloma virus (HPV) in gastric cancer tissues. The genomes of 14 HPV subtypes of high oncogenic potential were assessed using quantitative polymerase chain reaction in 84 tumor samples. A stringent protocol for preventing sample contamination, and confirming the biological activity of the virus in the tumor cells, was applied. The study did not confirm either the presence of the HPV genome or viral activity in the examined tumor tissues.