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World J Gastroenterol. Jun 7, 2014; 20(21): 6615-6619
Published online Jun 7, 2014. doi: 10.3748/wjg.v20.i21.6615
Published online Jun 7, 2014. doi: 10.3748/wjg.v20.i21.6615
Telomerase and hTERT: Can they serve as markers for gastric cancer diagnosis?
Yong-Bo Cheng, Ping Yao, Gulimire∙Aerken, Department of Gastroenterology, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, Xinjiang Uygur Autonomous Region, China
Li-Ping Guo, Xiao-Yan Ning, Dian-Chun Fang, Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing 400038, China
Author contributions: Fang DC designed and provided financial support for this work; Cheng YB conducted the study and wrote the manuscript; Guo LP and Ning XY provided technical support for this study; Yao P and Aerken G revised the manuscript.
Supported by National Natural Science Foundation of China, No. 30270609
Correspondence to: Dr. Dian-Chun Fang, Department of Gastroenterology , Southwest Hospital , Third Military Medical University, 30 Gaotanyanzheng Road, Chongqing 400038, China. fangdianchun2012@163.com
Telephone: +86-23-68773055 Fax: +86-23-68773055
Received: November 30, 2013
Revised: February 23, 2014
Accepted: March 4, 2014
Published online: June 7, 2014
Revised: February 23, 2014
Accepted: March 4, 2014
Published online: June 7, 2014
Core Tip
Core tip: Telomerase activity and human telomerase reverse transcriptase (hTERT) protein expression were detected in normal human gastric mucosal epithelial cells isolated from human gastric tissues, and were similar to those found in cell lines from human gastric adenocarcinoma. The results of this study suggest that the use of telomerase or hTERT as diagnostic markers for gastric cancer may require further studies.