Ćulafić Đ, Štulić M, Obrenović R, Miletić D, Mijač D, Stojković M, Jovanović M, Ćulafić M. Role of cystatin C and renal resistive index in assessment of renal function in patients with liver cirrhosis. World J Gastroenterol 2014; 20(21): 6573-6579 [PMID: 24914379 DOI: 10.3748/wjg.v20.i21.6573]
Corresponding Author of This Article
Milica Ćulafić, MSc, Department of Pharmacokinetics and Clinical Pharmacy, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450 Street, 11000 Belgrade, Serbia. milica.culafic@gmail.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Case Control Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Đorđe Ćulafić, Danijela Miletić, Dragana Mijač, Milica Stojković, MilošŠtulić, Clinic of Gastroenterology and Hepatology, Clinical Center of Serbia, and School of Medicine, University of Belgrade, 11000 Belgrade, Serbia
Radmila Obrenović, Institute of Medical Biochemistry, Clinical Center of Serbia, 11000 Belgrade, Serbia
Marija Jovanović, Milica Ćulafić, Department of Pharmacokinetics and Clinical Pharmacy, Faculty of Pharmacy, University of Belgrade, 11000 Belgrade, Serbia
Author contributions: Ćulafić Đ and Štulić M contributed equally to this work; Ćulafić Đ and Štulić M designed the research; Ćulafić Đ, Štulić M, Miletić D, Mijač D and Stojković M performed the research; Obrenović R performed the biochemical analysis; Jovanović M and Ćulafić M analyzed the data; Ćulafić Đ, Štulić M and Ćulafić M wrote the paper.
Supported by Ministry of Education, Science and Technological Development, Belgrade, Republic of Serbia, Project No. 175036
Correspondence to: Milica Ćulafić, MSc, Department of Pharmacokinetics and Clinical Pharmacy, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450 Street, 11000 Belgrade, Serbia. milica.culafic@gmail.com
Telephone: +381-11-3951375 Fax: +381-11-3951373
Received: January 1, 2014 Revised: February 18, 2014 Accepted: March 19, 2014 Published online: June 7, 2014
Core Tip
Core tip: Early diagnosis of renal dysfunction is important to prevent serious complications. We conducted a study of 63 patients with liver cirrhosis and 30 healthy controls. Serum cystatin C (CysC) was measured and renal Doppler ultrasonography was performed. More patients with decreased glomerular filtration rate (GFR) were identified based on CysC GFR than on creatinine GFR. Higher renal resistive index in advanced disease by Child-Pugh and model of end stage liver disease was noticed. Renal resistive index (RRI) correlated with CysC and negatively correlated with glomerular filtration rate from serum cystatin C. Cystatin C may be a more reliable marker for liver insufficiency assessment. CysC and RRI represent sensitive indicators of renal dysfunction in liver cirrhosis.
