LncRNAs expression signatures of hepatocellular carcinoma revealed by microarray

doi:10.3748/wjg.v20.i20.6314

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May 28, 2014 (publication date) through Apr 26, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 28, 2014; 20(20): 6314-6321
Published online May 28, 2014. doi: 10.3748/wjg.v20.i20.6314

LncRNAs expression signatures of hepatocellular carcinoma revealed by microarray

Wu-Tao Liu, Xin Lu, Guang-Hua Tang, Jin-Jun Ren, Wen-Jun Liao, Peng-Lei Ge, Jie-Fu Huang

Wu-Tao Liu, Xin Lu, Guang-Hua Tang, Jin-Jun Ren, Wen-Jun Liao, Peng-Lei Ge, Jie-Fu Huang, Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China

Author contributions: Liu WT contributed to the conception and design of the study, and wrote the manuscript; Tang GH, Ren JJ, Liao WJ and Ge PL performed the research; Huang JF contributed to the conception and design of the study, and approved the final version to be published; Lu X collected the conception and designed the study, revised the article and approved the final version to be published.

Supported by Grants from the China Medical Board of New York, No. 11-045; and National Key Technology Research and Development Program of China, No. BAI06B01

Correspondence to: Xin Lu, MD, Professor of Surgery, Department of Liver Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No.1 Shuaifuyuan, Beijing 100730, China. luxinln@gmail.com

Telephone: +86-10-69156042 Fax: +86-10-69156043

Received: March 7, 2014
Revised: April 25, 2014
Accepted: May 12, 2014
Published online: May 28, 2014

Core Tip

Core tip: Long non-coding RNAs (lncRNAs) possess prominent and diverse regulatory functions in cancer processes. In this study, the expression profiles of lncRNAs in hepatocellular carcinoma (HCC) were analyzed using a microarray-based method. One hundred and seventy-one lncRNAs were significantly downregulated and 488 were upregulated in HCC tissues. Validation was performed in 29 subjects with HCC using quantitative real-time polymerase chain reaction and the expressions of four lncRNAs were significantly downregulated in HCC, whereas the expression of lncRNA MALAT1 showed no significant difference. The same result was obtained in a subset of patients with hepatitis B virus-related HCC.