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World J Gastroenterol. May 28, 2014; 20(20): 6262-6278
Published online May 28, 2014. doi: 10.3748/wjg.v20.i20.6262
Published online May 28, 2014. doi: 10.3748/wjg.v20.i20.6262
Management of chronic hepatitis B infection: Current treatment guidelines, challenges, and new developments
Ceen-Ming Tang, Tung On Yau, Jun Yu, Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, LKS Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China
Tung On Yau, Jun Yu, Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen 518057, Guangdong Province, China
Ceen-Ming Tang, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, United Kingdom
Author contributions: Tang CM wrote this review; Yau TO revised the article; and Yu J revised the article and supervised the work.
Supported by Collaborative Research Fund (CUHK3/CRF/12R; HKU3/CRF11R) of the Research Grant Council Hong Kong; National Basic Research Program of China, 973 Program, No. 2013CB531401; CUHK Focused Investments Scheme B to HY Lan; and Theme-based Research Scheme of the Hong Kong Research Grants Council, No. T12-403-11
Correspondence to: Jun Yu, MD, PhD, Professor, Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, LKS Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China. junyu@cuhk.edu.hk
Telephone: +852-3-7636099 Fax: +852-2-1445330
Received: October 21, 2013
Revised: November 24, 2013
Accepted: January 19, 2014
Published online: May 28, 2014
Revised: November 24, 2013
Accepted: January 19, 2014
Published online: May 28, 2014
Core Tip
Core tip: This article summarizes the different indications for treatment, and systematically reviews the evidence for the efficacy of various antiviral agents. It further discusses the shortcomings of current guidelines, use of rescue therapy in drug-resistant strains of hepatitis B virus, and highlights the promising clinical trials for emerging therapies in the pipeline. This concise overview presents an updated practical approach to guide the clinical management of chronic hepatitis B.