Published online May 28, 2014. doi: 10.3748/wjg.v20.i20.6252
Revised: December 22, 2013
Accepted: January 8, 2014
Published online: May 28, 2014
Core tip: Increasing evidence indicates that hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) may involve gender disparity and that it may be a type of hormone-responsive malignant tumor. Sex hormones have been shown to play very different roles in the progression of an HBV infection and in the development of HBV-related HCC. The article reviews the reported molecular mechanisms of the gender disparity in HBV-related HCC, with an aim to improve the understanding of the development and progression of HBV-associated HCC and exploring more effective prevention and treatment of this disease.