Published online May 28, 2014. doi: 10.3748/wjg.v20.i20.6244
Revised: December 30, 2013
Accepted: January 20, 2014
Published online: May 28, 2014
Core tip: The risk calculator is a useful tool in many fields of medicine, including hepatology. This paper reviews the history of the development and validation of risk calculators of hepatocellular carcinoma (HCC) for patients with chronic hepatitis B (CHB). The rationale for using HCC risk calculators is first given, followed by a description of the course and pathway towards deriving HCC risk estimation tools for treatment-free CHB patients. Examples of the application of HCC risk prediction tools in clinical and public health settings is also shown. The paper also discusses several issues raised by the application of HCC risk scores.