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World J Gastroenterol. May 28, 2014; 20(20): 6159-6169
Published online May 28, 2014. doi: 10.3748/wjg.v20.i20.6159
Aetiology and risk factors of ischaemic cholangiopathy after liver transplantation
Moustafa Mabrouk Mourad, Abdullah Algarni, Christos Liossis, Simon R Bramhall
Moustafa Mabrouk Mourad, Abdullah Algarni, Christos Liossis, Simon R Bramhall, Liver Unit, Queen Elizabeth Hospital, Birmingham B15 2TH, United Kingdom
Author contributions: Mourad MM designed the study; Mourad MM, Algarni A, Liossis C collected, analysed, interpreted the data, and drafted the article; Bramhall SR designed the conception, critically revised the manuscript for important intellectual content, and made the final approval of the version to be published.
Correspondence to: Moustafa Mabrouk Mourad, MS, MRCS, Liver Unit, Queen Elizabeth Hospital, Nuffield House 3rd Floor, Edgbaston, Birmingham B15 2TH, United Kingdom. moustafa.mourad@nhs.net
Telephone: +44-742-7365931 Fax: +44-121-4141833
Received: October 28, 2013
Revised: January 26, 2014
Accepted: March 19, 2014
Published online: May 28, 2014
Core Tip

Core tip: Biliary complications after liver transplantation represent a major challenge. Ischaemic cholangiopathy is a set of disorders characterized by multiple diffuse intrahepatic strictures. Ischaemic cholangiopathy can cause a late graft loss. It becomes more evident after the widespread usage of grafts after circulatory deaths. Awareness of predisposing factors, presentation, diagnosis, and management is mandatory. Prophylaxis is essential by controlling risk factors. Management varies from simple radiological interventions to re-transplantation.