Published online May 28, 2014. doi: 10.3748/wjg.v20.i20.6092
Revised: February 1, 2014
Accepted: March 19, 2014
Published online: May 28, 2014
Core tip: Although there is still controversy about whether capecitabine-based regimes can replace 5-fluorouracil (5-FU) in clinical practice in the treatment of first-line metastatic colon cancer, we have reviewed most of different randomized studies and meta-analyses, and we can conclude that capecitabine appear to be an effective, safe, convenient, and economically viable alternative to 5-FU.