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World J Gastroenterol. May 28, 2014; 20(20): 5962-5972
Published online May 28, 2014. doi: 10.3748/wjg.v20.i20.5962
miR-106b-25/miR-17-92 clusters: Polycistrons with oncogenic roles in hepatocellular carcinoma
Weiqi Tan, Yang Li, Seng-Gee Lim, Theresa MC Tan
Weiqi Tan, Theresa MC Tan, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore S117597, Singapore
Yang Li, Seng-Gee Lim, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore S117597, Singapore
Author contributions: All authors contributed equally to the paper.
Correspondence to: Dr. Theresa MC Tan, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, MD7, 8 Medical Drive, Singapore S117597, Singapore. bchtant@nus.edu.sg
Telephone: +65-1-65163685 Fax: +65-1-67791453
Received: October 27, 2013
Revised: January 11, 2014
Accepted: April 1, 2014
Published online: May 28, 2014
Core Tip

Core tip: The polycistronic miR-17-92 cluster has been characterized to play a role in tumorigenesis. Over-expression of the miR-17-92 cluster and its paralog, the miR-106b-25 cluster, has been reported in the development of cirrhosis and hepatocellular carcinoma. Various targets of these microRNAs have been identified, and these targets are involved in tumor growth, cell survival and metastasis. We describe the regulation of these clusters by c-Myc and E2F1, and discuss the roles of the various members of the clusters in affecting relevant target gene expression in the pathogenesis of hepatocellular carcinoma.