Published online May 28, 2014. doi: 10.3748/wjg.v20.i20.5962
Revised: January 11, 2014
Accepted: April 1, 2014
Published online: May 28, 2014
Core tip: The polycistronic miR-17-92 cluster has been characterized to play a role in tumorigenesis. Over-expression of the miR-17-92 cluster and its paralog, the miR-106b-25 cluster, has been reported in the development of cirrhosis and hepatocellular carcinoma. Various targets of these microRNAs have been identified, and these targets are involved in tumor growth, cell survival and metastasis. We describe the regulation of these clusters by c-Myc and E2F1, and discuss the roles of the various members of the clusters in affecting relevant target gene expression in the pathogenesis of hepatocellular carcinoma.