Prognostic factors for hepatocellular carcinoma recurrence

doi:10.3748/wjg.v20.i20.5935

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May 28, 2014 (publication date) through Apr 26, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. May 28, 2014; 20(20): 5935-5950
Published online May 28, 2014. doi: 10.3748/wjg.v20.i20.5935

Prognostic factors for hepatocellular carcinoma recurrence

Antonio Colecchia, Ramona Schiumerini, Alessandro Cucchetti, Matteo Cescon, Martina Taddia, Giovanni Marasco, Davide Festi

Antonio Colecchia, Ramona Schiumerini, Martina Taddia, Giovanni Marasco, Davide Festi, Department of Gastrointestinal Diseases and Internal Medicine, University of Bologna, 40138 Bologna, Italy

Alessandro Cucchetti, Matteo Cescon, Department of General Surgery and Transplants, University of Bologna, 40138 Bologna, Italy

Author contributions: Colecchia A, Schiumerini R, Taddia M and Marasco G collected the data available regarding the medical aspects of hepatocellular recurrence; Cucchetti A and Cescon M collected the data available regarding the surgical aspects of hepatocellular recurrence; Colecchia A and Festi D wrote the manuscript.

Correspondence to: Antonio Colecchia, MD, Department of Gastrointestinal Diseases and Internal Medicine, University of Bologna, Via Massarenti 9, 40138 Bologna, Italy. antonio.colecchia@aosp.bo.it

Telephone: +39-51-6364110 Fax: +39-51-6364110

Received: September 25, 2013
Revised: February 20, 2014
Accepted: April 27, 2014
Published online: May 28, 2014

Core Tip

Core tip: Hepatocellular carcinoma (HCC) recurrence represents an important clinical challenge due to its negative impact on overall patient survival. The predictors of HCC recurrence, based mainly on HCC radiological features (i.e., number and size of HCC nodules), have enabled early diagnosis thereby drastically reducing the HCC recurrence rate and, hence, patient survival. However, other more efficacious predictors are needed in order to further reduce the HCC recurrence rate. This review describes the more clinically useful predictors of the different imaging techniques and the molecular features of HCC recurrence according to the available therapeutic strategies.