Case Report
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World J Gastroenterol. May 21, 2014; 20(19): 5918-5923
Published online May 21, 2014. doi: 10.3748/wjg.v20.i19.5918
Two rare gastric hamartomatous inverted polyp cases suggest the pathogenesis of growth
Hirohito Mori, Hideki Kobara, Takaaki Tsushimi, Shintaro Fujihara, Noriko Nishiyama, Tae Matsunaga, Maki Ayaki, Tatsuo Yachida, Tsutomu Masaki
Hirohito Mori, Hideki Kobara, Shintaro Fujihara, Noriko Nishiyama, Tae Matsunaga, Maki Ayaki, Tatsuo Yachida, Tsutomu Masaki, Department of Gastroenterology and Neurology, Kagawa University School of Medicine, 1750-1 Ikenobe, Miki, Kita, Kagawa 761-0793, Japan
Hirohito Mori, Takaaki Tsushimi, Department of Gastroenterological Surgery, Ehime Rosai Hospital, 13-27, Minamikomatsubara, Niihama, Ehime 792-8550, Japan
Author contributions: Mori H was responsible for devising the research and writing the manuscript; Kobara H, Tsushimi T, Fujihara S, Nishiyama N, Matsunaga T, Ayaki M and Yachida T participated equally in the work; Masaki T provided a critical revision of the manuscript for intellectual content and was responsible for the final approval of the manuscript.
Correspondence to: Hirohito Mori, MD, PhD, Department of Gastroenterology and Neurology, Kagawa University School of Medicine, 1750-1 Ikenobe, Miki, Kita, Kagawa 761-0793, Japan. hiro4884@med.kagawa-u.ac.jp
Telephone: +81-87-8912156 Fax: +81-87-8912158
Received: November 25, 2013
Revised: December 27, 2013
Accepted: March 4, 2014
Published online: May 21, 2014
Core Tip

Core tip: The pathogeneses of hamartomatous inverted polyps (HIP) and inverted hyperplastic polyps remain controversial. Our experience with 2 rare successive cases of HIP suggests that after a hamartomatous change occurs in the submucosal layer, some of these components are exposed to the gastric mucosa and, consequently, form a hypertrophic lesion. An en bloc resection by endoscopic submucosal dissection is recommended for treatment.