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World J Gastroenterol. May 14, 2014; 20(18): 5493-5504
Published online May 14, 2014. doi: 10.3748/wjg.v20.i18.5493
Published online May 14, 2014. doi: 10.3748/wjg.v20.i18.5493
Growth inhibition of hepatocellular carcinoma tumor endothelial cells by miR-204-3p and underlying mechanism
Zhong-Hui Cui, Shi-Qiang Shen, Zu-Bing Chen, Chao Hu, Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China
Author contributions: Cui ZH performed the majority of experiments and contributed to this work; Chen ZB designed the study; Hu C contributed analytic tools; Cui ZH analyzed data and wrote the paper; and Shen SQ were involved in editing the manuscript.
Correspondence to: Shi-Qiang Shen, MD, Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China. swsw2212@sina.com
Telephone: +86-27-88041911 Fax: +86-27-88041911
Received: October 28, 2013
Revised: January 3, 2014
Accepted: February 26, 2014
Published online: May 14, 2014
Revised: January 3, 2014
Accepted: February 26, 2014
Published online: May 14, 2014
Core Tip
Core tip: This study first employed a microarray to detect differentially expressed miRNAs in hepatocellular carcinoma (HCC) tumor endothelial cells (TECs), as compared to hepatic sinusoidal endothelial cells with the goal of identifying specific miRNAs that play important roles in the angiogenesis of HCC. Our study proved that fibronectin 1 (FN1) is a potential target gene of miR-204-3p, suggesting that FN1 regulates the growth of HCC TECs via the miR-204-3p/FN1 signaling pathway. The underlying mechanism was also investigated to provide new targets and a theoretical basis for the anti-angiogenic gene therapy of HCC.