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World J Gastroenterol. May 7, 2014; 20(17): 5074-5081
Published online May 7, 2014. doi: 10.3748/wjg.v20.i17.5074
Published online May 7, 2014. doi: 10.3748/wjg.v20.i17.5074
Evaluation of routine biopsies in endoscopic screening for esophagogastric junction cancer
Xin Niu, Wen-Qiang Wei, Guo-Qing Wang, You-Lin Qiao, Department of Cancer Epidemiology, Cancer Institute/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China
Chang-Qing Hao, Department of Endoscopy, Linzhou Cancer Hospital, Linzhou 456500, Henan Province, China
Guo-Hui Song, Cixian Cancer Institute/Cancer Hospital, Cixian 056500, Hebei Province, China
Jun Li, Yanting Cancer Hospital, Yanting 621600, Sichuan Province, China
Zhao-Lai Hua, Yangzhong Cancer Hospital, Yangzhong 212210, Jiangsu Province, China
Yong-Wei Li, Shexian Cancer Registry, Shexian 056400, Hebei Province, China
Jun Chang, Taixing Center for Disease Control, Taixing 225400, Jiangsu Province, China
Xin-Zheng Wang, Yangcheng Cancer Hospital, Yangcheng 048100, Shanxi Province, China
De-Li Zhao, Department of Endoscopy, People’s Hospital of Feicheng, Feicheng 271600, Shandong Province, China
Evelyn Hsieh, Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520-1942, United States
Author contributions: Wei WQ and Qiao YL designed the research; Hao CQ, Song GH, Li J, Hua ZL, Li YW, Chang J, Wang XZ, Zhao DL and Wang GQ performed the research; Niu X reviewed the literature, analyzed the data and drafted the manuscript; Niu X, Wei WQ, Hsieh E and Qiao YL revised the manuscript.
Supported by National Natural Science Foundation of China, No. 81241091
Correspondence to: Wen-Qiang Wei, MD, PhD, Department of Cancer Epidemiology, Cancer Institute/Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, 17 South Panjiayuan Lane, PO Box 2258, Beijing 100021, China. weiwq@cicams.ac.cn
Telephone: +86-10-87788443 Fax: +86-10-67713648
Received: October 23, 2013
Revised: January 21, 2014
Accepted: March 5, 2014
Published online: May 7, 2014
Revised: January 21, 2014
Accepted: March 5, 2014
Published online: May 7, 2014
Core Tip
Core tip: Our findings offer population-level evidence for the high incidence spot of esophagogastric junction (EGJ) cancer. It is also the first study to evaluate whether the findings at the high incidence spot could be used in endoscopic screening in high-risk populations to increase the detection rate. We found that visible mucosal abnormalities of the EGJ at endoscopy were strongly associated with pathologic diagnoses of high-grade intraepithelial neoplasia or higher grade lesions. When no abnormalities were detected, routine biopsies from normal-appearing mucosa at the high incidence spot in endoscopic screening were unjustified in high-risk populations.