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World J Gastroenterol. Apr 28, 2014; 20(16): 4648-4661
Published online Apr 28, 2014. doi: 10.3748/wjg.v20.i16.4648
Published online Apr 28, 2014. doi: 10.3748/wjg.v20.i16.4648
Resveratrol inhibits collagen I synthesis by suppressing IGF-1R activation in intestinal fibroblasts
Ping Li, Ying Zhu, Yao-Yao Gong, Yun Wang, Ding Heng, Lin Lin, Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Mei-Lan Liang, Nanping First Hospital Affiliated to Fujian Medical University, Nanping 353000, Fujian Province, China
Author contributions: Li P and Lin L designed the research; Li P, Liang ML and Zhu Y performed the research; Gong YY, Wang Y and Heng D contributed new reagents or analytic tools; Li P analyzed the data; Li P and Lin L wrote the paper.
Supported by the National Natural Science Foundation of China, No. 81270462; the International Cooperation Project of Jiangsu Province Department of Health, No. SBZ201100103
Correspondence to: Lin Lin, MD, PhD, Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Rd, Nanjing 210029, Jiangsu Province, China. lin9100@aliyun.com
Telephone: +86-25-83718836-6920 Fax: +86-25-83674636
Received: November 14, 2013
Revised: January 13, 2014
Accepted: February 20, 2014
Published online: April 28, 2014
Revised: January 13, 2014
Accepted: February 20, 2014
Published online: April 28, 2014
Core Tip
Core tip: This study showed that the expression of silent information regulator 1 (SIRT1) was decreased in 2,4,6-trinitrobenzenesulfonic acid-induced colitis tissues, and resveratrol down-regulated insulin growth factor (IGF)-1-induced collagen I synthesis by inhibiting IGF-1 receptor (IGF-1R) phosphorylation and its downstream extracellular signal-regulated kinase/mitogen-activated protein kinase signaling pathway in intestinal fibroblasts. Resveratrol alone suppressed collagen I synthesis through up-regulating activity of SIRT1. Our data highlight a previously unknown function of resveratrol on IGF-1R activation and provide novel insight of resveratrol as a therapeutic agent for intestinal fibrosis.