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World J Gastroenterol. Apr 21, 2014; 20(15): 4407-4413
Published online Apr 21, 2014. doi: 10.3748/wjg.v20.i15.4407
Published online Apr 21, 2014. doi: 10.3748/wjg.v20.i15.4407
HBsAg levels in HBeAg-positive chronic hepatitis B patients with different immune conditions
Yi-Min Zhang, Yi-Da Yang, Hong-Yu Jia, Lin-Yan Zeng, Wei Yu, Ning Zhou, Lan-Juan Li, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, China
Author contributions: Zhang YM and Yang YD contributed equally to this paper; Li LJ designed the study; Jia HY, Zeng LY, Yu W and Zhou N collected the data; Zhang YM and Yang YD collected and analyzed the data and wrote the paper.
Supported by China National Science and Technology Major Project, No. 2012ZX10002004 and No. 2013ZX10002001; the Chinese High Tech Research and Development (863) Program, No. 2011AA020104; Zhejiang CTM Science and Technology Project, No. 2011ZB061
Correspondence to: Lan-Juan Li, MD, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, No. 79 Qingchun Road, Shangcheng District, Hangzhou 310003, Zhejiang Province, China. ljli@zju.edu.cn
Telephone: +86-571-87236755 Fax: +86-571-87236755
Received: July 6, 2013
Revised: December 31, 2013
Accepted: February 17, 2014
Published online: April 21, 2014
Revised: December 31, 2013
Accepted: February 17, 2014
Published online: April 21, 2014
Core Tip
Core tip: This study showed that a dramatic immune response demonstrated that acute on chronic liver failure results in lower serum hepatitis B surface antigen levels compared with a mild immune response in patients in the immune clearance phase. These findings may have important implications for understanding the immune clearance of hepatitis B virus in these patients.