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World J Gastroenterol. Apr 21, 2014; 20(15): 4362-4369
Published online Apr 21, 2014. doi: 10.3748/wjg.v20.i15.4362
Published online Apr 21, 2014. doi: 10.3748/wjg.v20.i15.4362
Comparative study of esomeprazole and lansoprazole in triple therapy for eradication of Helicobacter pylori in Japan
Tsutomu Nishida, Masahiko Tsujii, Hideki Iijima, Tetsuo Takehara, Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka 565-0871, Japan
Hirohisa Tanimura, Department of Gastroenterology, Osaka Kaisei Hospital, Osaka 532-0003, Japan
Shusaku Tsutsui, Department of Gastroenterology, Itami City Hospital, Itami 664-8540, Japan
Shingo Tsuji, Department of Gastroenterology, Osaka Seamen’s Insurance Hospital, Osaka 552-0021, Japan
Akira Takeda, Department of Gastroenterology, Ashiya Municipal Hospital, Ashiya 659-8502, Japan
Atsuo Inoue, Department of Gastroenterology, Osaka General Medical Center, Osaka 558-8558, Japan
Hiroyuki Fukui, Department of Gastroenterology, Yao Municipal Hospital, Yao 581-0069, Japan
Toshiyuki Yoshio, Department of Gastroenterology, Osaka National Hospital, Osaka 540-0006, Japan
Osamu Kishida, Department of Gastroenterology, Sumitomo Hospital, Osaka 565-0871, Japan
Hiroyuki Ogawa, Department of Gastroenterology, Nishinomiya Municipal Central Hospital, Nishinomiya 663-8014, Japan
Masahide Oshita, Department of Internal Medicine, Osaka Police Hospital, Osaka 543-0035, Japan
Ichizo Kobayashi, Department of Gastroenterology, Higashiosaka City General Hospital, Higashiosaka 578- 8588, Japan
Shinichiro Zushi, Department of Gastroenterology, Ikeda Municipal Hospital, Ikeda 563-0025, Japan
Makoto Ichiba, Department of Gastroenterology, Toyonaka Municipal Hospital, Toyonaka 560-0055, Japan
Naoto Uenoyama, Department of Gastroenterology, Otemae Hospital, Osaka 540-0008, Japan
Yuichi Yasunaga, Department of Gastroenterology, Hyogo Prefectural Nishinomiya Hospital, Nishinomiya 662-0918, Japan
Ryu Ishihara, Department of Gastrointestinal Oncology, Osaka Medical Center for Cancer and Cardiovascular Disease, Osaka 537-0025, Japan
Mamoru Yura, Department of Gastroenterology, Minoh City Hospital, Minoh 562-0014, Japan
Masato Komori, Department of Gastroenterology, Osaka Rosai Hospital, Sakai 591-8025, Japan
Satoshi Egawa, Department of Gastroenterology, Kansai Rosai Hospital, Amagasaki 660-8511, Japan
Author contributions: Nishida T wrote the manuscript; Nishida T, Tsujii M and Tsuji S concept and designed this study; Nishida T, Tsujii M, Tanimura H, Tsutsui S, Tsuji S, Takeda A, Inoue A, Fukui H, Yoshio T, Kishida O, Ogawa H, Oshita M, Kobayashi I, Zushi S, Ichiba M, Uenoyama N, Yasunaga Y, Ishihara R, Yura M, Komori M, Egawa S and Iijima H collected the data; Takehara T provided scientific editing and assisted with writing the manuscript.
Correspondence to: Tetsuo Takehara, MD, PhD, Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan. takehara@gh.med.osaka-u.ac.jp
Telephone: +81-6-68793621 Fax: +81-6-68793629
Received: November 19, 2013
Revised: December 31, 2013
Accepted: January 20, 2014
Published online: April 21, 2014
Revised: December 31, 2013
Accepted: January 20, 2014
Published online: April 21, 2014
Core Tip
Core tip: Amoxicillin is a standard regime for Helicobacter pylori (H. pylori) eradication in Japan. Esomeprazole is a second-generation PPI that became available in 2011 in Japan. Several studies have reported eradication data comparing esomeprazole to first-generation proton pump inhibitors (PPIs), but it is not known whether the H. pylori eradication rates of esomeprazole are equal to those of lansoprazole, a first-generation PPI, under circumstances of increased resistance to clarithromycin in Japan.