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World J Gastroenterol. Apr 7, 2014; 20(13): 3615-3619
Published online Apr 7, 2014. doi: 10.3748/wjg.v20.i13.3615
Published online Apr 7, 2014. doi: 10.3748/wjg.v20.i13.3615
Rabeprazole, clarithromycin, and amoxicillin Helicobacter pylori eradication therapy: Report of an efficacy study
Charles Asabamaka Onyekwere, Joan Nwabuaku Odiagah, Rufina Igetei, Amancia Olufunmilayo Duro Emanuel, Francis Ekere, Gastroenterology unit, Department of Medicine, Lagos State University Teaching Hospital, Ikeja, Lagos 999062, Nigeria
Stella Smith, Molecular Biology Department, NIMR Yaba, Lagos 999062, Nigeria
Author contributions: Onyekwere CA and Odiagah JN designed trial; Onyekwere CA, Odiagah JN, Duro Emanuel AO, Igetei R, Ekere F and Smith S collected data; Onyekwere CA, Odiagah JN contributed data analysis and manuscript writing; all approved final manuscript.
Correspondence to: Dr. Charles Asabamaka Onyekwere, Department of Medicine, Lagos State University Teaching Hospital, Mobolaji Bank Anthony Way, Ikeja, lagos 999062, Nigeria. ifymobi@yahoo.com
Telephone: +234-80-33080186 Fax: +234-1-7927468
Received: October 10, 2013
Revised: December 19, 2013
Accepted: January 3, 2014
Published online: April 7, 2014
Revised: December 19, 2013
Accepted: January 3, 2014
Published online: April 7, 2014
Core Tip
Core tip:Helicobacter pylori (H. pylori) infection is widespread in Nigeria, along with the associated risk of serious gastroduodenal diseases, including gastric cancer. The use of different eradication therapies for H. pylori is commonplace, as no consensus exists regarding the optimal treatment regimen, despite guidelines and recommendations. This lack of consensus is most likely due to the lack of evidence-based data, and the findings in this report may help to fill this gap.