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World J Gastroenterol. Apr 7, 2014; 20(13): 3542-3551
Published online Apr 7, 2014. doi: 10.3748/wjg.v20.i13.3542
Published online Apr 7, 2014. doi: 10.3748/wjg.v20.i13.3542
Anemia in inflammatory bowel disease: A neglected issue with relevant effects
Danila Guagnozzi, Alfredo J Lucendo, Department of Gastroenterology, Hospital General de Tomelloso, 13700 Tomelloso, Ciudad Real, Spain
Author contributions: Both authors contributed equally to this paper.
Correspondence to: Danila Guagnozzi, MD, Department of Gastroenterology, Hospital General de Tomelloso, Vereda de Socuéllamos, s/n. 13700 Tomelloso, Ciudad Real, Spain. danila_g@libero.it
Telephone: +34-926-525926 Fax: +34-926-525870
Received: October 12, 2013
Revised: November 22, 2013
Accepted: March 5, 2014
Published online: April 7, 2014
Revised: November 22, 2013
Accepted: March 5, 2014
Published online: April 7, 2014
Core Tip
Core tip: Anemia represents one of the major causes of both decreased quality of life and increased hospital admissions among inflammatory bowel disease (IBD) patients. This paper analyses the complex etiological and pathophysiological mechanisms underlying anemia in IBD, including iron and micronutrients deficiency, effects of proinflammatory mediators and bone marrow insufficiency secondary to the disease by itself and IBD therapy. By a comprehensive review of the current diagnostic and therapeutic evidences on anemia in IBD, an state-of-the-art approach will be provided to effectively manage this challenging and common condition.