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World J Gastroenterol. Apr 7, 2014; 20(13): 3534-3541
Published online Apr 7, 2014. doi: 10.3748/wjg.v20.i13.3534
Published online Apr 7, 2014. doi: 10.3748/wjg.v20.i13.3534
Pharmacogenetics of azathioprine in inflammatory bowel disease: A role for glutathione-S-transferase?
Gabriele Stocco, Marco Pelin, Giuliana Decorti, Department of Life Sciences, University of Trieste, I-34127 Trieste, Italy
Raffaella Franca, Sara De Iudicibus, Diego Favretto, Stefano Martelossi, Alessandro Ventura, Institute for Maternal and Child Health IRCCS Burlo Garofolo, I-34137 Trieste, Italy
Eva Cuzzoni, Alessandro Ventura, Department of Medical, Surgical and Health Sciences, University of Trieste, I-34127 Trieste, Italy
Author contributions: All authors participated in the preparation, writing and discussion of the manuscript.
Correspondence to: Gabriele Stocco, PhD, Department of Life Sciences, University of Trieste, via A. Fleming 22, I-34127 Trieste, Italy. stoccog@units.it
Telephone: +39-40-5588634 Fax: +39-40-5588634
Received: October 31, 2013
Revised: December 30, 2013
Accepted: January 19, 2014
Published online: April 7, 2014
Revised: December 30, 2013
Accepted: January 19, 2014
Published online: April 7, 2014
Core Tip
Core tip: Polymorphisms of glutathione-S-transferase-M1 may influence azathioprine effects in young patients with inflammatory bowel disease by increasing the drug activation and by modulating oxidative stress and apoptosis.