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World J Gastroenterol. Mar 28, 2014; 20(12): 3327-3334
Published online Mar 28, 2014. doi: 10.3748/wjg.v20.i12.3327
Published online Mar 28, 2014. doi: 10.3748/wjg.v20.i12.3327
Thiopurine-methyltransferase variants in inflammatory bowel disease: Prevalence and toxicity in Brazilian patients
Ana Teresa P Carvalho, Barbara C Esberard, Renata S B Fróes, Ana B Grinman, Disciplina de Gastroenterologia e Endoscopia Digestiva, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ 20551-900, Brazil
Tatiana A Simão, Luis Felipe Ribeiro-Pinto, Laboratório de Toxicologia e Biologia Molecular, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ 20551-900, Brazil
Davy C M Rapozo, Tatiana A Simão, Juliana C V C Santos, Luis Felipe Ribeiro-Pinto, Programa de Carcinogênese Molecular, Instituto Nacional de Câncer, Rio de Janeiro, RJ 20230-130, Brazil
Antonio José V Carneiro, Heitor S P de Souza, Serviço de Gastroenterologia, Departamento de Clínica Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941-913, Brazil
Author contributions: Carvalho ATP and Esberard BC participated in the conception and design of the study, the acquisition, analysis, and interpretation of data, and the drafting of the manuscript; Fróes RSB, Rapozo DCM, Grinman AB, Simão TA, Santos JCVC and Carneiro AJV participated in the acquisition, analysis, and interpretation of the data and the drafting of parts of the manuscript; Ribeiro-Pinto LF and de Souza HSP participated in the conception and design of the study, obtained funding, analyzed and interpreted data, and critically revised the manuscript for important intellectual content; all authors gave final approval of the submitted version of the manuscript.
Supported by Brazilian research agencies CNPq and FAPERJ for financial support
Correspondence to: Heitor S P de Souza, MD, Serviço de Gastroenterologia, Departamento de Clínica Médica, Universidade Federal do Rio de Janeiro. Rua Prof. Rodolpho Paulo Rocco, 255, Ilha do Fundão, Rio de Janeiro, RJ 21941-913, Brazil. heitor.souza@gmail.com
Telephone: +55-21-25622669 Fax: +55-21-25622669
Received: September 7, 2013
Revised: November 8, 2013
Accepted: November 28, 2013
Published online: March 28, 2014
Revised: November 8, 2013
Accepted: November 28, 2013
Published online: March 28, 2014
Core Tip
Core tip: Although commonly used to treat patients with inflammatory bowel disease, the potentially severe side effects of azathioprine remain a concern. To determine a patient’s predisposition to azathioprine toxicity, the thiopurine-methyl-transferase genotype must be determined prior to azathioprine administration.