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World J Gastroenterol. Mar 28, 2014; 20(12): 3301-3311
Published online Mar 28, 2014. doi: 10.3748/wjg.v20.i12.3301
Published online Mar 28, 2014. doi: 10.3748/wjg.v20.i12.3301
Regulatory effect and mechanisms of carbon monoxide-releasing molecule II on hepatic energy metabolism in septic mice
Feng Liang, Jie Cao, Wei-Ting Qin, Xu Wang, Xue-Feng Qiu, Bing-Wei Sun, Department of Burn and Plastic Surgery, Affiliated Hospital, Jiangsu University, Zhenjiang 212001, Jiangsu Province, China
Author contributions: Liang F, Cao J and Sun BW designed research; Liang F, Qin WT, Cao J and Qiu XF performed the experiment; Cao J and Qiu XF contributed new reagents/analytic tools; Sun BW and Liang F analyzed data; Sun BW wrote the paper.
Supported by National Natural Science Foundation of China, No. 30772256, No. 81071546 and No. 81272148; and Natural Science Foundation of Jiangsu Province, China, No. BK2012703
Correspondence to: Bing-Wei Sun, MD, PhD, Professor, Department of Burn and Plastic Surgery, Affiliated Hospital, Jiangsu University, 438 Jiefang Road, Zhenjiang 212001, Jiangsu Province, China. sunbinwe@hotmail.com
Telephone: +86-511-85082258 Fax: +86-511-85029089
Received: November 11, 2013
Revised: December 20, 2013
Accepted: February 20, 2014
Published online: March 28, 2014
Revised: December 20, 2013
Accepted: February 20, 2014
Published online: March 28, 2014
Core Tip
Core tip: This study used an exogenous carbon monoxide (CO) intervention for the first time and 18F-fluorodeoxyglucose/micro-positron emission tomography to detect hepatic glucose metabolism in vivo in septic mice. The protective effect of CO on hepatic mitochondria in septic mice was examined, and its regulatory effect on abnormal glucose metabolism was explored. The results will provide new evidence for potentially improving outcomes as a consequence of exogenous CO on the survival rate in septic patients.