Copyright
©2014 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Mar 28, 2014; 20(12): 3255-3264
Published online Mar 28, 2014. doi: 10.3748/wjg.v20.i12.3255
Published online Mar 28, 2014. doi: 10.3748/wjg.v20.i12.3255
Dysregulation of mucosal immune response in pathogenesis of inflammatory bowel disease
Xiao-Rong Xu, Chang-Qin Liu, Bai-Sui Feng, Zhan-Ju Liu, Department of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University, Shanghai 200072, China
Author contributions: Xu XR and Liu CQ collected the materials and wrote the manuscript; Feng BS reviewed the manuscript; Liu ZJ designed and supervised this work.
Supported by Grants from the National Natural Science Foundation of China, No. 81061120521 and No. 81270470; Shanghai Science and Technology Commission, No. 12XD1404000
Correspondence to: Zhan-Ju Liu, MD, PhD, Professor, Department of Gastroenterology, Shanghai Tenth People’s Hospital, Tongji University, No. 301 Yanchang Road, Shanghai 200072, China. zhanjuliu@yahoo.com
Telephone: +86-21-66301164 Fax: +86-21-66303893
Received: September 20, 2013
Revised: November 13, 2013
Accepted: January 6, 2014
Published online: March 28, 2014
Revised: November 13, 2013
Accepted: January 6, 2014
Published online: March 28, 2014
Core Tip
Core tip: The etiology and pathology of inflammatory bowel disease (IBD) remain elusive, and dysregulation of the mucosal immune response toward commensal bacterial flora together with genetic and environmental factors may play important roles in the pathogenesis of IBD. A better understanding of the mechanisms of immune responses in the intestinal mucosa will provide new insights into the pathogenesis of IBD, and shed some light on targeted immune therapy for this disease.