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World J Gastroenterol. Mar 28, 2014; 20(12): 3153-3163
Published online Mar 28, 2014. doi: 10.3748/wjg.v20.i12.3153
Published online Mar 28, 2014. doi: 10.3748/wjg.v20.i12.3153
Management of intestinal failure in inflammatory bowel disease: Small intestinal transplantation or home parenteral nutrition?
Elizabeth Harrison, Philip Allan, Amrutha Ramu, Simon Lal, Intestinal Failure Unit, Salford Royal NHS Foundation Trust, Greater Manchester M6 8HD, United Kingdom
Philip Allan, Amrutha Ramu, Simon Travis, Translational Gastroenterology Unit, Oxford University Hospitals NHS Trust, Oxford OX3 6RP, United Kingdom
Anil Vaidya, Transplant Centre, Oxford University Hospitals NHS Trust, Oxford OX3 7LE, United Kingdom
Author contributions: Lal S devised, reviewed and edited the article; Harrison E and Allan P wrote and edited the article; Ramu A, Vaidya A and Travis S reviewed and edited the article.
Correspondence to: Dr. Elizabeth Harrison, Intestinal Failure Unit, Salford Royal NHS Foundation Trust, Greater Manchester M6 8HD, United Kingdom. elizabeth.harrison-3@manchester.ac.uk
Telephone: +44-161-2061442 Fax: +44-161-2061442
Received: September 28, 2013
Revised: November 21, 2013
Accepted: January 14, 2014
Published online: March 28, 2014
Revised: November 21, 2013
Accepted: January 14, 2014
Published online: March 28, 2014
Core Tip
Core tip: In this review we describe and compare the principal options for the management of intestinal failure in patients with inflammatory bowel disease: home parenteral nutrition and intestinal transplantation. We describe patient survival, complications and quality of life considerations that influence individualised decision-making between approaches. As survival from transplantation improves, decision-making is likely to change.