Copyright
©2014 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Jan 7, 2014; 20(1): 219-227
Published online Jan 7, 2014. doi: 10.3748/wjg.v20.i1.219
Published online Jan 7, 2014. doi: 10.3748/wjg.v20.i1.219
Susceptibility to ulcerative colitis in Hungarian patients determined by gene-gene interactions
Patricia Sarlos, 1st Department of Internal Medicine, University of Pecs, 7623 Pecs, Hungary
Dalma Varszegi, Department of Dermatology, Venereology and Oncodermatology, University of Pecs, 7624 Pecs, Hungary
Veronika Csongei, Department of Immunology and Biotechnology, University of Pecs, 7624 Pecs, Hungary
Lili Magyari, Luca Jaromi, Bela Melegh, Department of Medical Genetics, University of Pecs, 7624 Pecs, Hungary
Veronika Csongei, Lili Magyari, Luca Jaromi, Bela Melegh, Szentagothai Research Centre, 7624 Pecs, Hungary
Lajos Nagy, Institute of Family Medicine, University of Pecs, 7632 Pecs, Hungary
Author contributions: Sarlos P, Varszegi D, Csongei V, Magyari L, Jaromi L, Nagy L and Melegh B contributed equally to this work; Sarlos P, and Nagy L wrote the manuscript; Sarlos P, Csongei V, and Jaromi L performed the statistical analyses; Varszegi D, Magyari L and Melegh B carried out the experiments.
Supported by The Grant of the Hungarian Science Foundation Nos. OTKA K103983 and T73430
Correspondence to: Bela Melegh, MD, PhD, DSc, Department of Medical Genetics, University of Pecs, Szigeti 12, 7624 Pecs, Hungary. bela.melegh@aok.pte.hu
Telephone: +36-72-536427 Fax: +36-72-536427
Received: August 28, 2013
Revised: September 29, 2013
Accepted: December 13, 2013
Published online: January 7, 2014
Revised: September 29, 2013
Accepted: December 13, 2013
Published online: January 7, 2014
Core Tip
Core tip: Most of the identified inflammatory bowel disease genes individually have only modest effects on inflammatory bowel disease susceptibility, suggesting that complex interactions are more important. The authors investigated the gene-gene interactions of the inflammatory bowel disease-5 loci and IL23R susceptibility alleles in a Hungarian ulcerative colitis cohort. The exploration of high risk genotype combinations could further add to our knowledge about the development of ulcerative colitis and could facilitate the diagnosis of high-risk patients.