Nakamura S, Matsumoto T. Helicobacter pylori and gastric mucosa-associated lymphoid tissue lymphoma: Recent progress in pathogenesis and management. World J Gastroenterol 2013; 19(45): 8181-8187 [PMID: 24363507 DOI: 10.3748/wjg.v19.i45.8181]
Corresponding Author of This Article
Shotaro Nakamura, MD, PhD, Department of R/D for Surgical Support System, Center for Advanced Medical Innovation, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan. shonaka@intmed2.med.kyushu-u.ac.jp
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Topic Highlight
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World J Gastroenterol. Dec 7, 2013; 19(45): 8181-8187 Published online Dec 7, 2013. doi: 10.3748/wjg.v19.i45.8181
Helicobacter pylori and gastric mucosa-associated lymphoid tissue lymphoma: Recent progress in pathogenesis and management
Shotaro Nakamura, Takayuki Matsumoto
Shotaro Nakamura, Department of R/D for Surgical Support System, Center for Advanced Medical Innovation, Kyushu University, Fukuoka 812-8582, Japan
Shotaro Nakamura, Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
Takayuki Matsumoto, Division of Gastroenterology, Department of Internal Medicine, Iwate Medical University, Morioka 020-8505, Japan
Author contributions: Nakamura S and Matsumoto T contributed equally to this manuscript.
Correspondence to: Shotaro Nakamura, MD, PhD, Department of R/D for Surgical Support System, Center for Advanced Medical Innovation, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan. shonaka@intmed2.med.kyushu-u.ac.jp
Telephone: +81-92-6424733 Fax: +81-92-6424741
Received: September 25, 2013 Revised: October 22, 2013 Accepted: November 3, 2013 Published online: December 7, 2013
Core Tip
Core tip: Recent progress in the research regarding the molecular pathogenesis and management of gastric mucosa-associated lymphoid tissue (MALT) lymphoma is reviewed. Helicobacter pylori (H. pylori) eradication leads to complete disease remission in 50%-90% of cases. In H. pylori-independent cases, activation of nuclear factor κB pathway by chromosomal translocations such as t(11;18)/API2-MALT1, or inactivation of A20 are considered to contribute to the lymphomagenesis. A recent Japanese multicenter study confirmed the excellent long-term outcome of gastric MALT lymphoma after H. pylori eradication. Strategies for patients not responding to H. pylori eradication should be tailored in consideration of clinical stage and the disease extent in each patient.
