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World J Gastroenterol. Nov 21, 2013; 19(43): 7778-7787
Published online Nov 21, 2013. doi: 10.3748/wjg.v19.i43.7778
Published online Nov 21, 2013. doi: 10.3748/wjg.v19.i43.7778
Amelioration of carbon tetrachloride-induced cirrhosis and portal hypertension in rat using adenoviral gene transfer of Akt
Gang Deng, Xiang-Jun Huang, Hong-Wu Luo, Fei-Zhou Huang, Xun-Yang Liu, Yong-Heng Wang, Department of Hepatobiliary and Pancreatic Surgery, the Third Xiangya Hospital of Central South University, Changsha 410013, Hunan Province, China
Author contributions: Huang FZ, Liu XY and Wang YH participated in research design and other authors collectively contributed to the performance of laboratory measurements; Deng G, Huang XJ and Huang FZ were involved in data collection and analysis; and Deng G, Huang XJ and Luo HW wrote the manuscript.
Correspondence to: Hong-Wu Luo, MD, Department of Hepatobiliary and Pancreatic Surgery, the Third Xiangya Hospital of Central South University, Changsha 410013, Hunan Province, China. luohongwuzny@sina.com
Telephone: +86-731-88618230 Fax: +86-731-88618030
Received: June 30, 2013
Revised: August 28, 2013
Accepted: September 15, 2013
Published online: November 21, 2013
Revised: August 28, 2013
Accepted: September 15, 2013
Published online: November 21, 2013
Core Tip
Core tip: In the present study, we have demonstrated for the first time that Ad-myr-HA-Akt virus was a useful tool to prevent carbon tetrachloride-induced cirrhosis in rat model. Our data obtained at different levels, from function to histological changes, apoptosis rate of hepatocytes, activation of hepatic stellate cells, deposition of collagen, portal vein pressure and NO level, which were all consistently and collectively supported the hypothesis that introduction of Ad-myr-HA-Akt virus inhibits the development of cirrhosis.