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World J Gastroenterol. Nov 21, 2013; 19(43): 7766-7771
Published online Nov 21, 2013. doi: 10.3748/wjg.v19.i43.7766
Published online Nov 21, 2013. doi: 10.3748/wjg.v19.i43.7766
PU.1-silenced dendritic cells prolong allograft survival in rats receiving intestinal transplantation
Xing-Wei Xu, Chuan-Rong Zhu, Wu Ji, Jie-Shou Li, Jinling Hospital, Research Institute of General Surgery, Nanjing University, School of Medicine, Nanjing 210002, Jiangsu Province, China
Bo-Wen Ding, Department of General Surgery, Xuzhou Hospital of Traditional Chinese Medicine, Xuzhou 221001, Jiangsu Province, China
Author contributions: Ji W designed the research and analyzed the data; Xu XW performed the research, analyzed the data and wrote the paper; Ding BW and Zhu CR performed the research; and Li JS guided and supervised the research.
Supported by A grant from the Natural Science Foundation of Jiangsu Province, China, No. BK2008237
Correspondence to: Wu Ji, MD, Professor, Jinling Hospital, Research Institute of General Surgery, Nanjing University, School of Medicine, No.305, East Zhongshan Road, Xuanwu District, Nanjing 210002, Jiangsu Province, China. jiwusky@126.com
Telephone: +86-25-80863334 Fax: +86-25-80863334
Received: July 20, 2013
Revised: September 5, 2013
Accepted: September 29, 2013
Published online: November 21, 2013
Revised: September 5, 2013
Accepted: September 29, 2013
Published online: November 21, 2013
Core Tip
Core tip: The inhibition of dendritic cells (DCs) maturation can promote their tolerogenicity in transplantation. PU.1 is a newly discovered transcription factor which is required for the regulation of dendritic cell maturation in all DCs subsets. We silenced the PU.1 gene using siRNA and showed, for the first time, that PU.1-silenced DCs had immune tolerance. This may be a new strategy to prevent graft rejection following intestinal transplantation.