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World J Gastroenterol. Nov 21, 2013; 19(43): 7758-7765
Published online Nov 21, 2013. doi: 10.3748/wjg.v19.i43.7758
Published online Nov 21, 2013. doi: 10.3748/wjg.v19.i43.7758
MicroRNA-143 suppresses gastric cancer cell growth and induces apoptosis by targeting COX-2
Xiao-Li Wu, Bin Cheng, Pei-Yuan Li, Huan-Jun Huang, Qiu Zhao, Zi-Li Dan, De-An Tian, Department of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Peng Zhang, Department of Gastrointestinal Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China
Author contributions: Wu XL performed the majority of experiments and wrote the manuscript; Cheng B, Li PY, Huang HJ, Zhao Q and Dan ZL provided vital reagents and analytical tools; Tian DA provided financial support for this work; and Zhang P designed the study and edited the manuscript.
Correspondence to: Peng Zhang, MD, PhD, Department of Gastrointestinal Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, Hubei Province, China. zhangpeng@tjh.tjmu.edu.cn
Telephone: +86-27-83665256 Fax: +86-27-83665256
Received: May 30, 2013
Revised: September 20, 2013
Accepted: September 29, 2013
Published online: November 21, 2013
Revised: September 20, 2013
Accepted: September 29, 2013
Published online: November 21, 2013
Core Tip
Core tip: MicroRNA-143 (miR-143) has been reported to be a tumor suppressor. However, the functions of miR-143-5p and miR-143-3p have never been compared. In this study, we found that both miR-143-5p and miR-143-3p function as tumor suppressors in gastric cancer; however, miR-143-5p alone directly targets cyclooxygenase-2, and it exhibits a stronger tumor suppressive effect than miR-143-3p.