Fouad H, Raziky MSE, Aziz RAA, Sabry D, Aziz GMA, Ewais M, Sayed AR. Dendritic cell co-stimulatory and co-inhibitory markers in chronic HCV: An Egyptian study. World J Gastroenterol 2013; 19(43): 7711-7718 [PMID: 24282359 DOI: 10.3748/wjg.v19.i43.7711]
Corresponding Author of This Article
Hanan Fouad, Professor of Medical Biochemistry Department, Faculty of Medicine, Cairo University, 11562 Cairo, Egypt. hanan.fouad@kasralainy.edu.eg
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Brief Article
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Nov 21, 2013; 19(43): 7711-7718 Published online Nov 21, 2013. doi: 10.3748/wjg.v19.i43.7711
Dendritic cell co-stimulatory and co-inhibitory markers in chronic HCV: An Egyptian study
Hanan Fouad, Maissa Saeed El Raziky, Rasha Ahmed Abdel Aziz, Dina Sabry, Ghada Mahmoud Abdel Aziz, Manal Ewais, Ahmed Reda Sayed
Hanan Fouad, Dina Sabry, Medical Biochemistry Department, Faculty of Medicine, Cairo University, 11562 Cairo, Egypt
Maissa Saeed El Raziky, Rasha Ahmed Abdel Aziz, Gastroenterology and Tropical Department, Faculty of Medicine, Cairo University, 11562 Cairo, Egypt
Ghada Mahmoud Abdel Aziz, Manal Ewais, Ahmed Reda Sayed, Medical Biochemistry Department, Faculty of Medicine, Beni Sueif University, 19206 Kornish Al Nile, Bani Sweif, Egypt
Author contributions: Abdel Aziz RA, Sabry D, Abdel Aziz GM, Ewais M and Sayed AR contributed to conception and design of the study, acquisition of data, conducting laboratory analytical work, drafting and editing of the article and final revision and approval of the completed article; and Fouad H and El Raziky MS contributed to analysis and interpretation of data, collection of human biological materials, drafting and editing of the article, revising the article for intellectual content and final revision and approval of the completed article.
Correspondence to: Hanan Fouad, Professor of Medical Biochemistry Department, Faculty of Medicine, Cairo University, 11562 Cairo, Egypt. hanan.fouad@kasralainy.edu.eg
Telephone: +20-122-7474888 Fax: +20-2-23632297
Received: April 27, 2013 Revised: July 30, 2013 Accepted: August 4, 2013 Published online: November 21, 2013
Core Tip
Core tip: An assessment of the gene expression of co-stimulatory and a co-inhibitory marker (CD83, CD86, CD40, PD-L1) was conducted in patients with hepatitis C virus (HCV) infection and their correlations with viral load, hepatitis activity score and fibrosis grade were determined. There was a significant decrease in dendritic cell (DC) co-stimulatory markers in HCV infected subjects, where HCV uremic subjects exhibited a lower degree of reduced co-stimulatory markers. There was a significant increase in the DC co-inhibitory marker in HCV infected subjects, where HCV uremic subjects exhibited a lower degree of increased co-inhibitory marker. All DC markers were significantly correlated with HCV viral load, hepatitis activity index and fibrosis score.
