Role of sirtuins in ischemia-reperfusion injury

doi:10.3748/wjg.v19.i43.7594

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 19, Issue 43

This Article

Academic Content and Language Evaluation of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (6542)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-2) series.

Item

Count

PDF

489

HTML

4312

Figures (1-2)

127

Sum=4928

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

859

Download

755

Sum=1614

Nov 21, 2013 (publication date) through Apr 26, 2024

Times Cited of This Article

Times Cited (53)

Journal Information of This Article

Publication Name

World Journal of Gastroenterology

ISSN

1007-9327

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Review

World J Gastroenterol. Nov 21, 2013; 19(43): 7594-7602
Published online Nov 21, 2013. doi: 10.3748/wjg.v19.i43.7594

Role of sirtuins in ischemia-reperfusion injury

Eirini Pantazi, Mohamed Amine Zaouali, Mohamed Bejaoui, Emma Folch-Puy, Hassen Ben Abdennebi, Joan Roselló-Catafau

Eirini Pantazi, Mohamed Amine Zaouali, Mohamed Bejaoui, Emma Folch-Puy, Experimental Hepatic Ischemia-Reperfusion Unit, Institut of Biomedical Research of Barcelona-Spanish National Research Council, Barcelona, 08036 Catalonia, Spain

Hassen Ben Abdennebi, Molecular Biology and Anthropology applied to development and health (UR12ES11), Faculty of Pharmacy, Monastir 5000, Tunisia

Joan Roselló-Catafau, Experimental Pathology Department, Institute of Biomedical Research of Barcelona-Spanish National Research Council, Barcelona, 08036 Catalonia, Spain

Author contributions: Pantazi E, Zaouali MA, Folch-Puy E and Bejaoui M wrote the article and reviewed the literature; Ben Abdennebi H and Roselló-Catafau J made significant contributions to the design and revision of the manuscript; all authors have read and approved the final manuscript.

Supported by AGAUR, No. 2012FI_B00382, Generalitat de Catalunya, Barcelona, Spain, to Pantazi E; CSIC for the development program to Bejaoui M, No. I-COOP0005; The Fondo de Investigaciones Sanitarias, No. FIS PI12/00519

Correspondence to: Joan Rosello-Catafau, PhD, Experimental Pathology Department, Institute of Biomedical Research of Barcelona-Spanish National Research Council, C/ Rosselló 161, 7th floor, Barcelona, 08036 Catalonia, Spain. jrcbam@iibb.csic.es

Telephone: +34-93-3638300 Fax: +34-93-3638301

Received: June 28, 2013
Revised: September 16, 2013
Accepted: September 29, 2013
Published online: November 21, 2013

Core Tip

Core tip: Sirtuins are responsible for the regulation of protein activation by deacetylating a range of proteins that play important roles in the pathophysiology of various diseases. The present review summarizes the beneficial effects of sirtuins 1 and 3, the two most prominent sirtuins involved in mammalian energy homeostasis and oxidative stress. We conclude that both sirtuins might be attractive targets for counteracting the detrimental effects of ischemia-reperfusion injury.