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World J Gastroenterol. Nov 14, 2013; 19(42): 7461-7471
Published online Nov 14, 2013. doi: 10.3748/wjg.v19.i42.7461
Published online Nov 14, 2013. doi: 10.3748/wjg.v19.i42.7461
Combined radiochemotherapy in patients with locally advanced pancreatic cancer: A meta-analysis
Yue Chen, Department of Radiology, Renji Hospital of Shanghai Jiaotong University School of Medicine, Shanghai 200001, China
Xian-Jun Sun, Department of Combined Traditional Chinese and Western Medicine for Liver, Gallbladder and Pancreas Diseases, Minhang Branch, Fudan University Shanghai Cancer Center, Shanghai 201100, China
Ting-Hui Jiang, Ai-Wu Mao, Intervention Center, Tongren Branch, Renji Hospital of Shanghai Jiaotong University School of Medicine, Shanghai 200050, China
Author contributions: All the authors were involved in the design of the protocol and assessment of the studies identified; Chen Y and Sun XJ performed data entry and analysis; Jiang TH, Mao AW and Chen Y drafted the manuscript; all authors have read and approved the final version to be published.
Supported by Shanghai Science and Technology Development Fund, No. 10JC1412902
Correspondence to: Ai-Wu Mao, MD, Intervention Center, Tongren Branch, Renji Hospital of Shanghai Jiaotong University School of Medicine, No. 786, Yuyuan Road, Shanghai 200050, China. jiangyuewu777@gmail.com
Telephone: +86-21-62524259-3397 Fax: +86-21-62113884
Received: June 2, 2013
Revised: August 8, 2013
Accepted: August 20, 2013
Published online: November 14, 2013
Revised: August 8, 2013
Accepted: August 20, 2013
Published online: November 14, 2013
Core Tip
Core tip: To compare the long-term clinical efficacy of chemotherapy plus radiotherapy (CRT) with that of radiotherapy alone (RT) or chemotherapy alone (CT) for locally advanced pancreatic carcinoma (LAPC)，the authors analyzed the potential impact of CRT, CT or RT on the survival of the patients using meta-analysis methodologies. Meta-analysis showed that compared with CT or RT, CRT can benefit the long-term survival of LAPC patients, although it may also increase treatment-related toxicities.