Brief Article
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World J Gastroenterol. Nov 14, 2013; 19(42): 7440-7446
Published online Nov 14, 2013. doi: 10.3748/wjg.v19.i42.7440
Curcumin protects against acetaminophen-induced apoptosis in hepatic injury
Gang Li, Jun-Bao Chen, Chao Wang, Zhi Xu, Hao Nie, Xiao-Yan Qin, Xiao-Mei Chen, Quan Gong
Gang Li, Jun-Bao Chen, Chao Wang, Zhi Xu, Hao Nie, Xiao-Yan Qin, Xiao-Mei Chen, Quan Gong, Department of Immunology, School of Medicine, Yangtze University, Jingzhou 434023, Hubei Province, China
Author contributions: Li G and Chen JB performed the experiments, collected the data and wrote the manuscript; Wang C and Nie H designed the study and revised the manuscript; Xu Z, Qin XY and Chen XM performed the experiments and analyzed the data; Gong Q revised the manuscript.
Supported by National Natural Science Foundation of China, No. 81271872; Health Department of Hubei Province, No. XF2012-5; and Jingzhou Bureau of Science and Technology
Correspondence to: Quan Gong, PhD, Department of Immunology, School of Medicine, Yangtze University, No. 1, Nanhuan Road, Jingzhou 434023, Hubei Province, China. gongquan1998@163.com
Telephone: +86-716-8062733 Fax: +86-716-8062733
Received: June 5, 2013
Revised: August 26, 2013
Accepted: September 15, 2013
Published online: November 14, 2013
Core Tip

Core tip: Acetaminophen (APAP) and curcumin (CMN) were administrated intraperitoneally. The aim of the study was to explore whether CMN has effect on APAP-induced hepatic toxicity in vivo. The findings revealed that CMN protects against APAP-induced lipid peroxidation, oxidative stress and hepatocyte apoptosis.