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World J Gastroenterol. Nov 14, 2013; 19(42): 7341-7360
Published online Nov 14, 2013. doi: 10.3748/wjg.v19.i42.7341
Published online Nov 14, 2013. doi: 10.3748/wjg.v19.i42.7341
Physiological and molecular biochemical mechanisms of bile formation
Vasiliy Ivanovich Reshetnyak, V.A. Negovsky Scientific Research Institute of General Reanimatology, Russian Academy of Medical Sciences, 107031 Moscow, Russia
Author contributions: Reshetnyak VI solely contributed this article.
Correspondence to: Vasiliy Ivanovich Reshetnyak, MD, PhD, DSc, Professor, V.A. Negovsky Scientific Research Institute of General Reanimatology, Russian Academy of Medical Sciences, Petrovka str. 25-2, 107031 Moscow, Russia. v_reshetnyak@yahoo.com
Telephone: +7-495-6946505 Fax: +7-495-6946505
Received: June 28, 2013
Revised: September 27, 2013
Accepted: September 29, 2013
Published online: November 14, 2013
Revised: September 27, 2013
Accepted: September 29, 2013
Published online: November 14, 2013
Core Tip
Core tip: Over the past 50 years, significant progress has been made in understanding the mechanisms of bile formation and secretion. This became possible due to the advances of fundamental investigations in cell biology, molecular biology, genetics and biochemistry. Knowledge of physiological and biochemical basis of bile formation has implications for understanding the mechanisms of development of pathological processes, associated with diseases of the liver and biliary tract.