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World J Gastroenterol. Nov 7, 2013; 19(41): 7097-7105
Published online Nov 7, 2013. doi: 10.3748/wjg.v19.i41.7097
Published online Nov 7, 2013. doi: 10.3748/wjg.v19.i41.7097
C/EBP homologous protein deficiency aggravates acute pancreatitis and associated lung injury
Te-I Weng, Hsiao-Yi Wu, Department of Forensic Medicine, College of Medicine, National Taiwan University, Taipei 100, Taiwan
Te-I Weng, Department of Emergency Medicine, National Taiwan University Hospital, Taipei 100, Taiwan
Bo-Lin Chen, Institute of Toxicology, College of Medicine, National Taiwan University, Taipei 100, Taiwan
Jie-Yang Jhuang, Department of Pathology, Far Eastern Memorial Hospital, Taipei 220, Taiwan
Kuo-How Huang, Department of Urology, College of Medicine, National Taiwan University, Taipei 100, Taiwan
Chih-Kang Chiang, Departments of Integrated Diagnostics and Therapeutics and Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei 100, Taiwan
Shing-Hwa Liu, Institute of Toxicology, College of Medicine, and Department of Pediatrics, National Taiwan University Hospital and College of Medicine, Taipei 100, Taiwan
Author contributions: Weng TI and Liu SH contributed equally to this work; Weng TI and Chiang CK prepared the testing samples and analyzed the research data and wrote the manuscript; Wu HY, Chen BL, Jhuang JY and Huang KH collected/analyzed the research data and contributed to discussion; Liu SH designed the experiments and wrote/reviewed/edited the manuscript.
Supported by A research grant from the National Science Council of Taiwan, No. NSC97-2320-B-002-020-MY3
Correspondence to: Shing-Hwa Liu, PhD, Professor, Institute of Toxicology, College of Medicine, National Taiwan University, No. 1, Jen-Ai Road, Section 1, Taipei 100, Taiwan. shinghwaliu@ntu.edu.tw
Telephone: +886-2-23123456-88605 Fax: +886-2-23410217
Received: May 9, 2013
Revised: July 27, 2013
Accepted: August 17, 2013
Published online: November 7, 2013
Revised: July 27, 2013
Accepted: August 17, 2013
Published online: November 7, 2013
Core Tip
Core tip: We found that mice lacking C/EBP homologous protein (CHOP) had aggravated acute pancreatitis-induced increases in the severity of pancreatic pathology, pancreatitis-associated lung injury, and cytokines interleukin-6 and tumor necrosis factor-α levels compared with wild-type (WT) mice. Pancreatic apoptosis was also lower in Chop-/- mice than in WT mice during acute pancreatitis. These results suggest that CHOP exerts protective effects against acute pancreatitis and limits the spread of inflammatory damage to the lungs.