Copyright
©2013 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Oct 28, 2013; 19(40): 6928-6930
Published online Oct 28, 2013. doi: 10.3748/wjg.v19.i40.6928
Published online Oct 28, 2013. doi: 10.3748/wjg.v19.i40.6928
Angiotensin-II inhibitor (olmesartan)-induced collagenous sprue with resolution following discontinuation of drug
Jennifer A Nielsen, Division of Research, ProPath Laboratory, Dallas, TX 75247, United States
Anita Steephen, Texas Digestive Disease Consultants, Southlake, TX 76092, United States
Matthew Lewin, Division of Gastrointestinal Pathology, ProPath Laboratory, Dallas, TX 75247, United States
Author contributions: Nielsen JA, Steephen A and Lewin M contributed to the conception, design and acquisition of data, and approved the final version to be published; Steephen A analyzed and interpreted the endoscopy; Lewin M analyzed and interpreted the gastrointestinal pathology; Nielsen JA and Lewin M drafted the article and revised it critically for important intellectual content.
Correspondence to: Matthew Lewin, MD, Division of Gastrointestinal Pathology, ProPath Laboratory, 1355 River Bend Dr., Dallas, TX 75247, United States. matthew.lewin@propath.com
Telephone: +1-214-2371628 Fax: +1-214-2371743
Received: June 6, 2013
Revised: July 31, 2013
Accepted: August 17, 2013
Published online: October 28, 2013
Revised: July 31, 2013
Accepted: August 17, 2013
Published online: October 28, 2013
Core Tip
Core tip: Collagenous sprue (CS) is a pattern of small-bowel injury characterized histologically by marked villous blunting, intraepithelial lymphocytes, and thickened sub-epithelial collagen table. Clinically, patients present with diarrhea, abdominal pain, malabsorption, and weight loss, which raises suspicion of celiac disease. Clinicians should be aware of the possibility of drug-induced CS and potential reversibility after discontinuation of medication.