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World J Gastroenterol. Oct 28, 2013; 19(40): 6883-6887
Published online Oct 28, 2013. doi: 10.3748/wjg.v19.i40.6883
Published online Oct 28, 2013. doi: 10.3748/wjg.v19.i40.6883
Expression and significance of cyclooxygenase-2 mRNA in benign and malignant ascites
Jing Lu, Xiao-Feng Li, Li-Xia Kong, Su-Huan Liao, Department of Gastroenterology, the Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai 519000, Guangdong Province, China
Lin Ma, Department of Oncology, the Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai 519000, Guangdong Province, China
Chang-You Jiang, Health Bureau of Jinwan District, Zhuhai 519000, Guangdong Province, China
Author contributions: Lu J performed the research and drafted the article; Li XF designed the research and revised the article; Kong LX and Ma L critically revised the article; Liao SH and Jiang CY analyzed the data and interpreted the results.
Supported by Fund of Science and Technology Plan Project in Zhuhai, No. PC20061084
Correspondence to: Dr. Lin Ma, Department of Oncology, the Fifth Affiliated Hospital of Sun Yat-Sen University, No. 52, Meihua East Road, Zhuhai 519000, Guangdong Province, China. linma1227@hotmail.com
Telephone: +86-756-2528845 Fax: +86-756-2528845
Received: June 2, 2013
Revised: August 8, 2013
Accepted: September 3, 2013
Published online: October 28, 2013
Revised: August 8, 2013
Accepted: September 3, 2013
Published online: October 28, 2013
Core Tip
Core tip: Ascites is a common symptom caused by a variety of diseases, the differential diagnosis between benign ascites and malignant ascites is one of the most important issues in clinical practice. Cytologic examinations and ascites tumor markers can provide important evidence, but their sensitivity and specificity are far from satisfactory. Our study aimed to explore the difference in cyclooxygensae-2 (COX-2) mRNA expression among different diseases. Our research suggests that COX-2mRNA can be detected by reverse transcriptase polymerase chain reaction, but there are no significant differences in the expression of COX-2 mRNA among various disease types with benign or malignant ascites.