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©2013 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastroenterol. Oct 28, 2013; 19(40): 6784-6793
Published online Oct 28, 2013. doi: 10.3748/wjg.v19.i40.6784
Published online Oct 28, 2013. doi: 10.3748/wjg.v19.i40.6784
Clinical applications of next-generation sequencing in colorectal cancers
Tae-Min Kim, Sug-Hyung Lee, Yeun-Jun Chung, MRC Cancer Evolution Research Center, College of Medicine, The Catholic University of Korea, Seoul 137-701, South Korea
Yeun-Jun Chung, Sug-Hyung Lee, Integrated Research Center for Genome Polymorphism, Department of Microbiology, College of Medicine, The Catholic University of Korea, Seoul 137-701, South Korea
Sug-Hyung Lee, Department of Pathology, College of Medicine, The Catholic University of Korea, Seoul 137-701, South Korea
Author contributions: Kim TM and Chung YJ collected the materials and wrote the manuscript; Lee SH commented on the contents; Chung YJ supervised the manuscript.
Supported by Cancer Evolution Research Center (2012R1A5A2047939), South Korea
Correspondence to: Yeun-Jun Chung, MD, PhD, Professor, Director, Integrated Research Center for Genome Polymorphism, Department of Microbiology, College of Medicine, The Catholic University of Korea, 505 Banpo-dong, Socho-gu, Seoul 137-701, South Korea. yejun@catholic.ac.kr
Telephone: +82-2-22587343 Fax: +82-2-5370572
Received: April 25, 2013
Revised: July 22, 2013
Accepted: August 20, 2013
Published online: October 28, 2013
Revised: July 22, 2013
Accepted: August 20, 2013
Published online: October 28, 2013
Core Tip
Core tip: Next-generation sequencing (NGS)-driven genomic analyses are facilitating the genomic dissection of various types of human cancers, including colorectal cancer (CRC). This review contains an up-to-date summary of recent NGS-based CRC studies and an overview of how these efforts have advanced our understanding of colorectal carcinogenesis with novel biomarkers for genome-based cancer diagnosis and personalized cancer therapeutics.