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World J Gastroenterol. Oct 7, 2013; 19(37): 6170-6177
Published online Oct 7, 2013. doi: 10.3748/wjg.v19.i37.6170
Published online Oct 7, 2013. doi: 10.3748/wjg.v19.i37.6170
Alteration in gene expression profile and oncogenicity of esophageal squamous cell carcinoma by RIZ1 upregulation
Shang-Wen Dong, Dong Li, Cong Xu, Yuan-Guo Wang, Peng Zhang, Department of Cardiothoracic Surgery, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin 300052, China
Pei Sun, Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin 300070, China
Author contributions: Dong SW and Zhang P designed research; Li D, Xu C and Wang YG performed research; Sun P instructed the experiment; Li D and Xu C analyzed data; and Dong SW wrote the paper.
Supported by The National Natural Science Foundation of China, No. 81201945; Science Foundation of Tianjin Medical University, No. 2011KY08; Doctoral Program of Higher Education Research Fund, No. 20091202110009; and Natural Science Foundation of Tianjin, China, No. 10JCYBJC11300
Correspondence to: Peng Zhang, Professor, Department of Cardiothoracic Surgery, Tianjin Medical University General Hospital, Tianjin Medical University, No. 22, Qixiangtai Road, Heping District, Tianjin 300070, China. zhang_peng6036@yeah.net
Telephone: +86-22-60814720 Fax: +86-22-60814722
Received: June 13, 2013
Revised: July 23, 2013
Accepted: August 5, 2013
Published online: October 7, 2013
Revised: July 23, 2013
Accepted: August 5, 2013
Published online: October 7, 2013
Core Tip
Core tip: Retinoblastoma protein-interacting zinc finger gene 1 (RIZ1) transfection induced widespread changes in gene expression profile of cell line TE13, with 960 genes upregulated and 1163 downregulated. Most of the differentially expressed genes are associated with cell development, supervision of viral replication, lymphocyte costimulatory, and immune system development in esophageal cells. RIZ1 gene may be involved in multiple cancer pathways, such as cytokine receptor interaction and transforming growth factor beta signaling. Virus infection may also be an important factor in the development of esophageal cancer.