Cheng SH, Mai L, Zhu FQ, Pan XF, Sun HX, Cao H, Shu X, Ke WM, Li G, Xu QH. Influence of chronic HBV infection on superimposed acute hepatitis E. World J Gastroenterol 2013; 19(35): 5904-5909 [PMID: 24124337 DOI: 10.3748/wjg.v19.i35.5904]
Corresponding Author of This Article
Qi-Huan Xu, Professor, Department of Infectious Diseases, the Third Affiliated Hospital of Sun Yat-sen University, Tianhe District, Guangzhou 510630, Guangdong Province, China. xqh03030513@aliyun.com
Research Domain of This Article
Infectious Diseases
Article-Type of This Article
Brief Article
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Sep 21, 2013; 19(35): 5904-5909 Published online Sep 21, 2013. doi: 10.3748/wjg.v19.i35.5904
Influence of chronic HBV infection on superimposed acute hepatitis E
Si-Hong Cheng, Li Mai, Feng-Qin Zhu, Xing-Fei Pan, Hai-Xia Sun, Hong Cao, Xin Shu, Wei-Min Ke, Gang Li, Qi-Huan Xu
Si-Hong Cheng, Li Mai, Feng-Qin Zhu, Xing-Fei Pan, Hai-Xia Sun, Hong Cao, Xin Shu, Wei-Min Ke, Gang Li, Qi-Huan Xu, Department of Infectious Diseases, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China
Author contributions: Cheng SH and Mai L contributed equally to this work; Cheng SH, Mai L and Xu QH designed the research; Cheng SH, Mai L, Zhu FQ, Pan XF, Sun HX, Cao H, Shu X, Ke WM and Li G performed the research; Cheng SH, Mai L, Zhu FQ, Pan XF, Sun HX, Cao H and Shu X collected the data; Cheng SH and Mai L analyzed the data; Cheng SH, Mai L and Xu QH wrote the manuscript.
Correspondence to: Qi-Huan Xu, Professor, Department of Infectious Diseases, the Third Affiliated Hospital of Sun Yat-sen University, Tianhe District, Guangzhou 510630, Guangdong Province, China. xqh03030513@aliyun.com
Telephone: +86-20-85253179 Fax: +86-20-85253179
Received: May 5, 2013 Revised: July 24, 2013 Accepted: August 4, 2013 Published online: September 21, 2013
Core Tip
Core tip: Previous studies have shown that chronic hepatitis B virus (HBV) infection has a negative impact on superimposed acute hepatitis E. However, it remains unknown whether the disease severity of acute hepatitis E correlates with the underlying HBV replication status or with liver histological lesions. Our study showed that the disease severity of acute hepatitis E correlated not with the HBV replication status (based on the status of hepatitis B e antigen and HBV DNA), but rather with the presence of underlying cirrhosis. This finding raised the question of whether anti-HBV treatment improves the outcome of liver failure caused by HBV-hepatitis E virus superinfection. We found that anti-HBV treatment could not improve the prognosis of such liver failure.
