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Cheng SH, Mai L, Zhu FQ, Pan XF, Sun HX, Cao H, Shu X, Ke WM, Li G, Xu QH. Influence of chronic HBV infection on superimposed acute hepatitis E. World J Gastroenterol 2013; 19(35): 5904-5909 [PMID: 24124337 DOI: 10.3748/wjg.v19.i35.5904]
World J Gastroenterol. Sep 21, 2013; 19(35): 5904-5909 Published online Sep 21, 2013. doi: 10.3748/wjg.v19.i35.5904
Influence of chronic HBV infection on superimposed acute hepatitis E
Si-Hong Cheng, Li Mai, Feng-Qin Zhu, Xing-Fei Pan, Hai-Xia Sun, Hong Cao, Xin Shu, Wei-Min Ke, Gang Li, Qi-Huan Xu
Si-Hong Cheng, Li Mai, Feng-Qin Zhu, Xing-Fei Pan, Hai-Xia Sun, Hong Cao, Xin Shu, Wei-Min Ke, Gang Li, Qi-Huan Xu, Department of Infectious Diseases, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China
Author contributions: Cheng SH and Mai L contributed equally to this work; Cheng SH, Mai L and Xu QH designed the research; Cheng SH, Mai L, Zhu FQ, Pan XF, Sun HX, Cao H, Shu X, Ke WM and Li G performed the research; Cheng SH, Mai L, Zhu FQ, Pan XF, Sun HX, Cao H and Shu X collected the data; Cheng SH and Mai L analyzed the data; Cheng SH, Mai L and Xu QH wrote the manuscript.
Correspondence to: Qi-Huan Xu, Professor, Department of Infectious Diseases, the Third Affiliated Hospital of Sun Yat-sen University, Tianhe District, Guangzhou 510630, Guangdong Province, China. xqh03030513@aliyun.com
Telephone: +86-20-85253179 Fax: +86-20-85253179
Received: May 5, 2013 Revised: July 24, 2013 Accepted: August 4, 2013 Published online: September 21, 2013 Processing time: 139 Days and 8.9 Hours
Core Tip
Core tip: Previous studies have shown that chronic hepatitis B virus (HBV) infection has a negative impact on superimposed acute hepatitis E. However, it remains unknown whether the disease severity of acute hepatitis E correlates with the underlying HBV replication status or with liver histological lesions. Our study showed that the disease severity of acute hepatitis E correlated not with the HBV replication status (based on the status of hepatitis B e antigen and HBV DNA), but rather with the presence of underlying cirrhosis. This finding raised the question of whether anti-HBV treatment improves the outcome of liver failure caused by HBV-hepatitis E virus superinfection. We found that anti-HBV treatment could not improve the prognosis of such liver failure.
