Case Report
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World J Gastroenterol. Aug 21, 2013; 19(31): 5187-5194
Published online Aug 21, 2013. doi: 10.3748/wjg.v19.i31.5187
Complete response to multidisciplinary therapy in a patient with primary gastric choriocarcinoma
Kazuhiro Takahashi, Shigeki Tsukamoto, Ken Saito, Nobuhiro Ohkohchi, Katsu Hirayama
Kazuhiro Takahashi, Nobuhiro Ohkohchi, Division of Gastroenterological and Hepatobiliary Surgery, and Organ Transplantation, Department of Surgery, University of Tsukuba, Tsukuba 3058575, Japan
Shigeki Tsukamoto, Ken Saito, Katsu Hirayama, Department of Surgery, Hiraka General Hospital, Yokote 0138610, Japan
Author contributions: Takahashi K, Tsukamoto S, Saito K, Ohkohchi N and Hirayama K contributed equally to this work; Takahashi K and Tsukamoto S wrote the paper.
Correspondence to: Shigeki Tsukamoto, MD, PhD, Department of Surgery, Hiraka General Hospital, 3-1 Yatsukuchi, Maegou, Yokote 0138610, Japan.
Telephone: +81-182-325121 Fax: +81-182-333200
Received: April 2, 2013
Revised: June 7, 2013
Accepted: June 18, 2013
Published online: August 21, 2013
Core Tip

Core tip: We described a case of primary gastric choriocarcinoma with a complete response to multidisciplinary treatment including surgery, chemotherapy, and radiofrequency ablation (RFA). The patient has been alive with no evidence of disease for 10 years. To the best of our knowledge, this patient with recurrent primary gastric choriocarcinoma has achieved the longest survival. The present case is the first report of choriocarcinoma metastatic to the lung successfully treated with RFA. From our retrospective analysis of recurrent or unresectable primary gastric choriocarcinoma, we propose that gonadal choriocarcinoma regimens can be considered as first-line for primary gastric choriocarcinoma.