Brief Article
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World J Gastroenterol. Aug 21, 2013; 19(31): 5118-5124
Published online Aug 21, 2013. doi: 10.3748/wjg.v19.i31.5118
Rikkunshito improves globus sensation in patients with proton-pump inhibitor-refractory laryngopharyngeal reflux
Ryoji Tokashiki, Isaku Okamoto, Nobutoshi Funato, Mamoru Suzuki
Ryoji Tokashiki, Isaku Okamoto, Nobutoshi Funato, Mamoru Suzuki, Department of Otolaryngology, Tokyo Medical University, Tokyo 160-0023, Japan
Author contributions: Tokashiki R and Suzuki M were the study supervisors; Tokashiki R designed the study; Tokashiki R, Okamoto I and Funato N performed the research; Tokashiki R analysed the data; Tokashiki R wrote the paper; all authors critically reviewsed the manuscript.
Supported by Tsumura & Co.
Correspondence to: Dr. Ryoji Tokashiki, Department of Otolaryngology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinkjyukuku, Tokyo 160-0023, Japan. tokachanman@yahoo.co.jp
Telephone: +81-3-33426111 Fax: +81-3-33469275
Received: January 17, 2013
Revised: February 20, 2013
Accepted: April 9, 2013
Published online: August 21, 2013
Core Tip

Core tip: Regarding the treatment of laryngopharyngeal reflux (LPR) symptoms such as globus sensation and a scratchy feeling, proton pump inhibitors (PPIs) are considered the mainstay. We investigated the effects of rikkunshito on globus sensation and gastric emptying in patients with PPI-refractory LPR.