Published online Aug 21, 2013. doi: 10.3748/wjg.v19.i31.5111
Revised: April 23, 2013
Accepted: May 8, 2013
Published online: August 21, 2013
Core tip: The aim of the present study was to evaluate the clinical accuracy of a new point-of-care device that is based on deamidated gliadin peptides (DGP) for diagnosis of celiac disease (CD). One-hundred-and-twelve patients with clinical symptoms suggestive of CD and/or first-degree relatives of CD patients, and patients with confirmed CD on a gluten-free diet, were prospectively enrolled in the study. The actual CD diagnosis had been based on serum-positive immunoglobulin A anti-tissue transglutaminase results by enzyme-linked immunosorbent assay and on biopsy findings. Overall evaluation shows that the new DGP-based rapid point-of-care test is an excellent screening tool for high-risk populations.