Published online Aug 21, 2013. doi: 10.3748/wjg.v19.i31.5085
Revised: June 5, 2013
Accepted: July 17, 2013
Published online: August 21, 2013
Core tip: Radix curcumae (RC), a common Chinese crude drug, has a wide range of pharmacological activity including hypolipidemic effect, hepatoprotective effect, anti-tumor, anti-radiation and anti-anaphylaxis. RC-derived diterpenoid C is recently obtained from RC ether extract by us, and its chemical properties and constitution are different from curcumin and β-elemene. Our results showed that RC-derived diterpenoid C can block nuclear factor kappa B signal pathway, effectively reducing the secretion of Helicobacter pylori-induced proinflammatory cytokine and increasing the secretion of anti-inflammatory cytokine. RC-derived diterpenoid C may become an effective drug for treatment of chronic gastritis.