Effects of radix curcumae-derived diterpenoid C on Helicobacter pylori-induced inflammation and nuclear factor kappa B signal pathways

doi:10.3748/wjg.v19.i31.5085

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Original Article

World J Gastroenterol. Aug 21, 2013; 19(31): 5085-5093
Published online Aug 21, 2013. doi: 10.3748/wjg.v19.i31.5085

Effects of radix curcumae-derived diterpenoid C on Helicobacter pylori-induced inflammation and nuclear factor kappa B signal pathways

Xuan Huang, Bin Lv, Shuo Zhang, Qun Dai, Bing-Bing Chen, Li-Na Meng

Xuan Huang, Bin Lv, Shuo Zhang, Qun Dai, Bing-Bing Chen, Li-Na Meng, Department of Gastroenterology, the First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou 310006, Zhejiang Province, China

Author contributions: All authors made substantial contributions to conception and design, drafting the article and revising it critically for important intellectual content; and all authors approved the version to be published.

Supported by The Natural Science Foundation of Zhejiang Province of China, No. LY12H29002; and by grants of Scientific Research from Chinese Herbal Drug Administration, No. 2011ZB032

Correspondence to: Bin Lv, Professor, Department of Gastroenterology, the First Affiliated Hospital, Zhejiang Chinese Medical University, Youdian Road 54, Shangcheng District, Hangzhou 310006, Zhejiang Province, China. lvbin@medmail.com.cn

Telephone: +86-571-86620281 Fax: +86-571-86620281

Received: April 20, 2013
Revised: June 5, 2013
Accepted: July 17, 2013
Published online: August 21, 2013

Core Tip

Core tip: Radix curcumae (RC), a common Chinese crude drug, has a wide range of pharmacological activity including hypolipidemic effect, hepatoprotective effect, anti-tumor, anti-radiation and anti-anaphylaxis. RC-derived diterpenoid C is recently obtained from RC ether extract by us, and its chemical properties and constitution are different from curcumin and β-elemene. Our results showed that RC-derived diterpenoid C can block nuclear factor kappa B signal pathway, effectively reducing the secretion of Helicobacter pylori-induced proinflammatory cytokine and increasing the secretion of anti-inflammatory cytokine. RC-derived diterpenoid C may become an effective drug for treatment of chronic gastritis.