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World J Gastroenterol. Aug 7, 2013; 19(29): 4689-4701
Published online Aug 7, 2013. doi: 10.3748/wjg.v19.i29.4689
Published online Aug 7, 2013. doi: 10.3748/wjg.v19.i29.4689
Garcinia Cambogia attenuates diet-induced adiposity but exacerbates hepatic collagen accumulation and inflammation
Young-Je Kim, Myung-Sook Choi, Department of Food Science and Nutrition, Kyungpook National University, Daegu 702-701, South Korea
Myung-Sook Choi, Un Ju Jung, Center for Food and Nutritional Genomics Research, Kyungpook National University, Daegu 702-701, South Korea
Yong Bok Park, Sang Ryong Kim, School of Life Sciences and Biotechnology, Kyungpook National University, Daegu 702-701, South Korea
Sang Ryong Kim, Brain Science and Engineering Institute, Kyungpook National University, Daegu 702-701, South Korea
Mi-Kyung Lee, Department of Food and Nutrition, Sunchon National University, Jeonnam 540-742, South Korea
Author contributions: Kim YJ and Choi MS contributed equally to this work; Kim YJ performed experiments and analyzed the data; Choi MS designed the study and reviewed and revised the manuscript; Park YB, Kim SR and Lee MK contributed to the critical edition of the manuscript; Jung UJ designed the study, performed experiments, analyzed the data and wrote the manuscript.
Supported by The Basic Science Research Program, No. 2011-0022387; and the SRC program, Center for Food and Nutritional Genomics: No. 2012-0000644 through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology
Correspondence to: Un Ju Jung, PhD, Center for Food and Nutritional Genomics Research, Kyungpook National University, 1370 San-Kyuk Dong, Puk-Ku, Daegu 702-701, South Korea. jungunju@naver.com
Telephone: +82-53-9507937 Fax: +82-53-9581230
Received: March 22, 2013
Revised: May 15, 2013
Accepted: June 1, 2013
Published online: August 7, 2013
Revised: May 15, 2013
Accepted: June 1, 2013
Published online: August 7, 2013
Core Tip
Core tip:Garcinia Cambogia (GC) is a popular dietary supplement for weight loss. However, little is known about the efficacy and hepatotoxicity of long-term GC supplementation in mice fed a high-fat diet (HFD). We observed that GC ameliorated HFD-induced adiposity by modulating enzymatic activity and gene expression involved in fatty acid metabolism. GC also reduced the plasma resistin level and glucose intolerance. However, GC caused hepatic collagen accumulation, inflammation and oxidative stress without affecting hepatic steatosis.