Published online Jul 14, 2013. doi: 10.3748/wjg.v19.i26.4262
Revised: April 24, 2013
Accepted: May 7, 2013
Published online: July 14, 2013
Core tip: In this report, we present the first case of a white opaque substance (WOS)-positive gastric hyperplastic polyp (HP) with dysplasia. We performed immunohistochemical staining using a monoclonal antibody specific for adipophilin as a marker of lipid droplets. According to endoscopic and histopathological findings, the WOS-positive epithelium corresponded to the dysplasia in this lesion. The presence of a WOS in a gastric HP may be considered an endoscopic finding that is predictive of the neoplastic transformation of a gastric HP. We suggest that patients with a WOS-positive gastric HP should be treated by endoscopic resection to investigate the neoplastic transformation of the HP.